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Why are naked mole rats the most long-lived rodents in the world?

(University of Rochester photo / J. Adam Fenster)

All people on our planet want to be healthy and live as long as possible, but the world is full of dangerous diseases. However, despite the efforts of thousands of scientists from all over the world to develop a cure for cancer and other deadly diseases, few today are able to survive at least 100 years. With all this, animals live near us, which can boast of longevity and protection from disease and without any medication. One of them is naked mole rats, which have a record life for rodents of up to 30 years. The study, the results of which were published in a scientific journal Biogerontology, revealed the secret of their longevity.

Naked diggers cannot be called the cutest creatures on the planet.

Naked mole rats (Heterocephalus glaber) are not the most pleasant looking animals, but the features of their body are truly amazing. For example, they are completely fearless of pain from thermal and chemical burns, and also have a strong immunity to cancer. Previously, scientists believed that diggers are completely protected against cancer but in 2016 they still managed to find a couple of individuals with cancerous tumors. However, their cancer incidence rate is extremely low and they survive to the age of 30. For comparison, the lifespan of mice does not exceed two years.

What is the secret of longevity of naked diggers?

According to scientists, the secret of longevity of naked diggers is hidden in their living conditions. As a rule, these unusual animals are found in dry savannahs and semi-deserts. But they do not live on a hot surface, but in underground tunnels at a depth of about 2 meters. The length of the underground passages can reach 5 kilometers, and the width of the tunnels is about 4 centimeters. It is also known that these excavators live in colonies of 70-80 individuals. Perhaps the longevity of these animals is associated with life in cold conditions with a minimum amount of oxygen.

Naked diggers live in narrow tunnels underground

To test this assumption, scientists from Ukraine and Israel decided to conduct a rather serious experiment. Its essence was that they took three groups of young, adult and elderly laboratory mice and placed them in conditions in which naked mole rats live. In the first part of the experiment, the animals were kept for several hours in a vessel with a closed lid. In the second part of the experiment, the mice lived for three months in a cage with 10% oxygen and carbon dioxide.

Is it possible to live without oxygen?

Being closed in a vessel without air, the mice began to inhale three times less oxygen and exhale less carbon dioxide. Also, in individuals of all ages, body temperature dropped. From all this, scientists concluded that the metabolism of animals slowed significantly.

In conditions with insufficient oxygen, rodents began to eat 50% less and lost almost 30% of their weight. But with all this they did not feel stress and behaved almost the same way as under normal conditions. The most surprising discovery for researchers was that mice living in the stuffy stuff heal faster. They checked this by making small cuts on their bodies – they dragged on faster for several days than usual.

Scientists were able to change the metabolic rate of mice

In the end, scientists found that under the new conditions the metabolism of laboratory rats changed and became almost the same as in naked mole rats. At the same time, rodents found the same property to heal more quickly from wounds, so the researchers decided that the secret of longevity of diggers is hidden in their living conditions. Of course, while this is not the final verdict, because they still have to do a lot of research.

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Science & Technology

Japan has developed an inflatable scooter that weighs practically nothing

The University of Tokyo engineers have developed the Poimo inflatable electric scooter, which is created individually for each owner. It is enough to send your photo to the manufacturers – and a personal optimized model will be assembled for you.

The scooter is designed with a special program for the body size of a particular user and his specific fit. Moreover, each owner is free to make any changes to this model. If he makes any changes to the drawing, the program will automatically redesign the electric bike to maintain its strength, stability and controllability. When the model is finished and approved, it is handed over to the manufacturer.

Scooter Poimo

The scooter consists of seven separate inflatable sections that are constructed from durable fabric and sewn with straight stitch. It remains to add electronic components – in particular, a brushless motor and a lithium-ion battery. 

The finished electric scooter weighs about 9 kg and can travel at speeds up to 6 km / h (that is, slightly faster than a pedestrian). It can work for an hour on one charge.

This is how the current version of Poimo looks like in action:

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Excerpts from Elon Musk’s speech at the Martian Society convention

Elon Musk’s comments with questions relayed from the Mars Society Membership by Dr. Robert Zubrin, James L. Burk, and Carie Fay. Following Elon’s 30 min time, Dr. Zubrin took additional questions. This special event was part of the 2020 Mars Society Virtual Convention from October 14-18, 2020.

About Starship Test Schedule:

– entering orbit – with a probability of 80% -90% will take place in 2021

– the probability of the return of the ship and the 1st stage in this flight is 50%

– test of refueling in orbit – 2022

– Starship lunar version – 2022 or 2023

– Starship flight to Mars – around 2024

The goal of the Starship is to build a self-sufficient settlement on Mars as quickly as possible. Musk does not rule out the possibility that this will not be achieved during his lifetime. According to his rough estimates, to create a self-sufficient city, it will be necessary to deliver 1 million tons of cargo, which corresponds to 4-5 million tons in a low Earth orbit. Modern single-use launch vehicles are capable of removing less than 1% of this value.

“Disposable launch vehicles are completely stupid. They are a waste of time. I think people need to stop wasting time on this. If you try to sell a disposable plane, you will be thrown out of the office. If you try to sell a disposable car, you will also be thrown out of the office. “

A series of questions and answers followed:

What is the best landing site on Mars?

– I’m not sure about that. But I can name the criteria. The first of these is latitude: most likely it will be in the northern hemisphere, far enough to the north to have water ice, but to still have enough sunlight.It also needs to be low to get the most benefit from atmospheric braking.

How do you prioritize mission priorities: research, infrastructure construction, and science?

– The first will be the construction of a fuel plant.

A question from a teenager who wants to become an engineer and robot maker with a dream to work at SpaceX: what is the most important education in order to become an engineer?

– There are many varieties of this profession: you can be an aerospace engineer, in the field of electronics, software, or a chemical engineer involved in creating safe production of fuels. I think physics is a good foundation for critical thinking.

Boring Company was originally conceived as a tunnel manufacturing firm on Mars?

– No. It was originally something of a joke. I thought tunnels were a good solution to reduce the traffic problem in cities and improve the quality of life by turning parking lots into green parks. To do this, you need to go to 3d [get away from the “flat” infrastructure – approx. per.]. I think tunnels are good for Mars too. But there you need a lot lighter equipment: you don’t care about mass on Earth, but you will have to take care of it a lot when going to Mars.

At Boring Company, have you learned a lot of technology that might come in handy on Mars?

– I think, yes.

Do you have any tips for young people who love Mars but don’t know how to participate in its settlement?

– I think any strong advocate of the need to conquer Mars matters. People often don’t even think about it. I often talk to people who don’t even know about it. Therefore, I consider it important for humanity and consciousness in general to bring a discussion about this to society. Talking about it with friends and acquaintances – I think this is what we should do. In my estimate, we will spend less than 1% of our efforts on Mars exploration, exactly less than healthcare, perhaps even less than cosmetics – this will be enough to make life multi-planetary. But this requires people to start talking about it 100 times more often. I think this is what really matters. [the entire cosmonautics of the world is $ 424 billion a year, while cosmetics is $ 532 billion, and tobacco production is $ 849 billion – approx. per.]

What’s the coolest part about Starship development?

– I think the coolest detail is the ability to work with a great group of engineers and come up with interesting solutions. I think the best thing is the opportunity to work with smart and creative people who come up with solutions that were not available before. This is a great reward.

What do you focus on when hiring, especially with regard to engineers?

“We’re looking for signs of exceptional ability. Or at the very least, striving to do exceptional things at SpaceX.

Are you planning to make a Mars-Earth communication system like Starlink?

– Yes, I think we will use a laser, probably launched into orbit, to avoid atmospheric diffraction. Thus, it will be a laser beam going from the orbit of the Earth to the orbit of Mars. And also relay satellites in solar orbit, since the laser beam cannot be sent through the Sun [when it is between Mars and Earth – approx. per.].

Can Starship be used for other destinations like Venus and other planets?

– Starship will be able to travel to any target in the solar system that has a solid surface when fuel depots appear. It is not the kind of transport that will take us to other stars, but when we become a multi-planetary species, we will create a demand for innovation in space travel that will ultimately lead us to interstellar travel.

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Cern Scientists Plan an Impressive Experiment – They Will Come Into A Parallel Universe

Cern scientists are once again preparing to impress the entire planet and become the focus of discussions with the new experiment they are planning.

An experiment that, if it brings the fascinating result that scientists have in mind,  will change the way we think about the world , will take place in the next few days at the Large Hadron Collider, the European nuclear center, Geneva CERN Research.

The astonishingly LHC complex, the largest, most energetic elemental accelerator in the world,  will be “fired” for the first time to its highest energy levels, in an effort to detect – or even create – tiny black holes. 

If it succeeds, then, a completely new universe will be revealed – rewriting not only the books of physics, but also the books of philosophy! 

It is possible, however,  that gravity from our universe will “leak” into this parallel universe, as LHC scientists say. 

From the Higgs boson to dark matter and the parallel universe

According to the British Express, the experiment is sure to “trigger” the critics, who are worried about the LHC, many of whom warn that the elementary particle accelerator will mark the end of our universe, creating a of the black hole.

Nevertheless,  Geneva has remained … intact since 2008, when the LHC began its spectacular “work”.

The first scientists at the Large Hadron Collider proved the existence of the Higgs boson – a key building block of the universe – and the LHC appears to be on track to locate “dark matter” – a previously undetectable force now considered that it constitutes the majority of matter in the universe, being, in fact, the reason why the latter is constantly expanding and moving away. 

So next week’s experiment is considered to change the game. 

The truth is out there

Mir Faizal, one of three heads of the three natural groups behind the experiment, said: 

“Like many parallel sheets, which are two-dimensional objects (width and length) can exist in a third dimension (height) , so parallel universes can also exist in higher dimensions. We anticipate that gravity can leak into extra dimensions, and if that happens, then tiny black holes can be produced in the LHC. 

Normally, when people think of the multiverse, they think of the interpretation of quantum mechanics by many worlds, where every possibility is realized. This cannot be tested and so it is a philosophy and not a science. We do not mean this with parallel universes. What we mean is real universes, in extra dimensions. The truth is out there.”

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