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New Drug Combo Could Repair the Brains of Alzheimer’s Patients

New Drug Combo Could Repair the Brains of Alzheimer’s Patients 86

Neuron Time

Neurons receive, process, and transmit all the impulses in our brains. Essentially, they’re the building blocks of the human nervous system, and once they’re damaged by Alzheimer’s disease or some other brain injury, they’re done for — they have no regenerative abilities.

In contrast, the glial cells that support and insulate neurons do have regenerative abilities, and now, researchers from Penn State think they’ve found an efficient way to actually transform glial cells into neurons — a discovery that could lead to a pill to repair brain damage.

Molecular Report

Based on a previous study, the Penn team knew it was possible to convert human glial cells into neurons using a sequence of nine tiny molecules. However, the large number of molecules and specific sequence made transitioning the research from the lab to something that could work in a clinical environment difficult.

In a study published in the journal Stem Cell Reports on Thursday, the Penn team describes how it found a way to streamline the process of creating neurons out of a type of glial cells called astrocytes with remarkable success.

“We identified the most efficient chemical formula among the hundreds of drug combinations that we tested,” researcher Jiu-Chao Yin said in a press release. “By using four molecules that modulate four critical signaling pathways in human astrocytes, we can efficiently turn human astrocytes — as many as 70 percent — into functional neurons.”

Dream Delivery

The Penn team acknowledged in the press release that it still has a long road ahead before its latest research will be able to help people with brain damage, but it’s extremely optimistic about the future.

“The most significant advantage of the new approach is that a pill containing small molecules could be distributed widely in the world, even reaching rural areas without advanced hospital systems,” research leader Gong Chen said.

“My ultimate dream is to develop a simple drug delivery system, like a pill, that can help stroke and Alzheimer’s patients around the world to regenerate new neurons and restore their lost learning and memory capabilities,” he continued. “Our years of effort in discovering this simplified drug formula take us one step closer to reaching our dream.”

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Science & Technology

The goal of human civilization is to create AI and disappear?

The goal of human civilization is to create AI and disappear? 91

Various sources often talk about civilizations that lived long before us. They all developed, prospered for a while, and then disappeared in an incomprehensible way. 

What is the reason for their decline, we probably will not know. All we can do is admire the remains of stone buildings, over which time has almost no power.

While looking for an answer, we somehow accidentally stumbled upon an interesting saying about the life of Japanese samurai: “A samurai has no goal, but a path.” In the end, the “path of the samurai” ended in what is known – death. The path of any civilization ended in the same way.

If you look at the issue through the prism of a samurai saying, then there is no point in looking for why and how civilization ended its existence. Probably, the process itself and its result are important here. But to whom is it important and what result does it expect?

Mysterious director

Apparently, behind the curtains of this “ancient theater” there is a mysterious “director” who periodically makes necessary adjustments to the history of civilization.

To figure out what’s what, you need to look at current trends in science. Where does a person strive with such an irresistible desire to “play God.” This attracts him and at the same time frightens him, but in no way turns him away from the intended path. Most likely, artificial intelligence (AI) is the purpose of our civilization’s existence.

About 50 years ago it would have seemed nonsense, but to someone, perhaps even now. However, if you trace the last 100 years of the life of our civilization, you get the feeling that most of the discoveries were given to mankind at the same time. A powerful leap has taken place in a hundred years. Why did it happen?

At the beginning of the last century, scientists recognized the existence of fields that have memory and the ability to store and transmit information. It is very likely that such or a similar field can be around the Earth and, more interesting, possess intelligence. Isn’t this the same “Director” hiding behind the screen of the “ancient theater”?

If this is so, then at a certain moment the “Director” gives the selected scientist “access” to certain knowledge (perhaps even in a dream, like Mendeleev), and another scientific breakthrough occurs in the world. Step by step, discovery after discovery, humanity is steadily moving towards the creation of AI. The trend is already well visible.

The goal of human civilization is to create AI and disappear? 92

AI is probably the next “Babylon”, which will combine all the knowledge, culture and accumulated experience of civilization. In the future, the neural network will enter into a connection with the general information field and leave humanity without knowledge, technology, and even a spoken language. This will be the next decline of civilization. And the “Director” will receive another array of new data (experience) in order to start creating a new civilization.

If someone believes that past civilizations ended in large-scale conflicts, then most likely this is already the consequences of “turning off” AI.

Co-founder of Skype talked about the threat of AI to humanity

One of the creators of the Skype internet call service, Jaan Ta

The goal of human civilization is to create AI and disappear? 93
Photo: 
© still from the movie “Terminator 2: Judgment Day”

llinn, said that the development of artificial intelligence (AI) threatens humanity. According to him, humans face three key threats, but it is AI that should be feared most of all, the expert said. 

Tallinn explained that at the moment, no one can predict what development AI will achieve in the next decades. In addition, the fact that scientists are creating artificial intelligence that can form a new AI without human intervention is also a cause for concern.

In addition, as the co-founder of the popular video calling service noted, the development of synthetic biology also causes concern. According to him, this direction in science allows the creation of artificial DNA sequences and biological systems that may not exist in nature.

Tallinn also drew attention to the fact that he fears we are entering an era of “unknown unknowns”, things that people are not even able to imagine right now.

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Volkswagen robot will autonomously charge cars: a working prototype presented

Volkswagen robot will autonomously charge cars: a working prototype presented 94
Copyright: © VW

The renowned German car manufacturer announced a new development. This time, engineers have created a unique robot capable of autonomously charging electric vehicles. 

For more than a year, specialists have been developing this project, but only now the concern was ready to demonstrate the first working prototype. The robot is ready to charge electric vehicles and has shown the high efficiency of this process.

It is called the Mobile Charging Robot, and experts have already compared it to the R2-D2 droid from Star Wars, including squeaks and clangs. Indeed, there is a similarity. Before implementing this idea, the engineers decided that robots should be allowed to charge cars parked in large residential complexes.

This will save their owners from leaving in order to find a gas station. Another advantage is that large parking lots and garages do not have to contain several expensive charging points for electric cars. The car company said in a press release that the robot works exclusively autonomously.

It independently controls and interacts with the vehicle being charged. It opens the cover of the charging socket and independently connects the power plug, then disconnects it. The robot looks like a trailer, which is a mobile energy storage.

It is capable of charging multiple electric vehicles at the same time. Despite the fact that the manufacturer confidently praises its concept, experts saw inefficiency in the fact that first it is necessary to charge the robot’s battery, which is then used to recharge electric cars.

Volkswagen Group Components CEO Thomas Schmall noted that creating an efficient charging infrastructure for the cars of the future is an important step in the company’s development.

Its engineers focus on finding solutions to avoid costly do-it-yourself measures. The mobile robot is only part of the concept that will continue to be developed.

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This video will forever change the way you think about time

This video will forever change the way you think about time 95

Business Insider, one of the world’s leading news portals, made a three-minute video that depicted the Earth’s timeline as a journey from Los Angeles to New York.

So, the beginning of the journey is 4.54 billion years ago, when the Earth was formed from the accumulation of gases and stardust. After some time, a significant event occurs – a giant space body crashes into the still not cooled Earth, as a result of which the breakaway part becomes its satellite – the Moon.

Further, the route runs through the mountains of Arizona, formed about 3.95 billion years ago. A few more kilometers to the east and we are at the 3.8 billion year mark. This is where the first evidence of life in the form of replicating molecules appears.

The next “stop” Kansas – 2.7 billion years ago. Cyanobacteria that produce oxygen appeared on Earth. It took the next 200 million years for the atmosphere of our planet to accumulate sufficient reserves of this most important gas.

Halfway through, we reach Pennsylvania. We are separated from it “only” by 660 million years. Life is developing rapidly: the Earth is covered with vegetation, amphibians are evolving. Unusual time travel is coming to an end – to the point “Now”. By the time the dinosaurs become extinct, we finally reach the outskirts of New York.

And where is the most important thing – people? To find out, you need to carve out three minutes and watch the entire video.

Source: Business Insider

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