This article was written by Dr. Kelly Brogan, posted here with permission.
Millions believe depression is caused by ‘serotonin deficiency,’ but where is the science in support of this theory?
“Depression is a serious medical condition that may be due to a chemical imbalance, and Zoloft works to correct this imbalance.”
Herein lies the serotonin myth.
As one of only two countries in the world that permits direct to consumer advertising, you have undoubtedly been subjected to promotion of the “cause of depression.” A cause that is not your fault, but rather; a matter of too few little bubbles passing between the hubs in your brain! Don’t add that to your list of worries, though, because there is a convenient solution awaiting you at your doctor’s office…
What if I told you that, in 6 decades of research, the serotonin (or norepinephrine, or dopamine) theory of depression and anxiety has not achieved scientific credibility?
You’d want some supporting arguments for this shocking claim.
So, here you go:
The Science of Psychiatry is Myth
Rather than some embarrassingly reductionist, one-deficiency-one-illness-one-pill model of mental illness, contemporary exploration of human behavior has demonstrated that we may know less than we ever thought we did. And that what we do know about root causes of mental illness seems to have more to do with the concept of evolutionary mismatch than with genes and chemical deficiencies.
In fact, a meta-analysis of over 14,000 patients and Dr. Insel, head of the NIMH, had this to say:
“Despite high expectations, neither genomics nor imaging has yet impacted the diagnosis or treatment of the 45 million Americans with serious or moderate mental illness each year.”
To understand what imbalance is, we must know what balance looks like, and neuroscience, to date, has not characterized the optimal brain state, nor how to even assess for it.
A New England Journal of Medicine review on Major Depression, stated:
” … numerous studies of norepinephrine and serotonin metabolites in plasma, urine, and cerebrospinal fluid as well as postmortem studies of the brains of patients with depression, have yet to identify the purported deficiency reliably.”
The data has poked holes in the theory and even the field of psychiatry itself is putting down its sword. One of my favorite essays by Lacasse and Leo has compiled sentiments from influential thinkers in the field – mind you, these are conventional clinicians and researchers in mainstream practice – who have broken rank, casting doubt on the entirety of what psychiatry has to offer around antidepressants:
Humble Origins of a Powerful Meme
In the 1950s, reserpine, initially introduced to the US market as an anti-seizure medication, was noted to deplete brain serotonin stores in subjects, with resultant lethargy and sedation. These observations colluded with the clinical note that an anti-tuberculosis medication, iproniazid, invoked mood changes after five months of treatment in 70% of a 17 patient cohort. Finally, Dr. Joseph Schildkraut threw fairy dust on these mumbles and grumbles in 1965 with his hypothetical manifesto entitled “The Catecholamine Hypothesis of Affective Disorders” stating:
“At best, drug-induced affective disturbances can only be considered models of the natural disorders, while it remains to be demonstrated that the behavioral changes produced by these drugs have any relation to naturally occurring biochemical abnormalities which might be associated with the illness.”
Contextualized by the ripeness of a field struggling to establish biomedical legitimacy (beyond the therapeutic lobotomy!), psychiatry was ready for a rebranding, and the pharmaceutical industry was all too happy to partner in the effort.
Of course, the risk inherent in “working backwards” in this way (noting effects and presuming mechanisms) is that we tell ourselves that we have learned something about the body, when in fact, all we have learned is that patented synthesized chemicals have effects on our behavior. This is referred to as the drug-based model by Dr. Joanna Moncrieff. In this model, we acknowledge that antidepressants have effects, but that these effects in no way are curative or reparative.
The most applicable analogy is that of the woman with social phobia who finds that drinking two cocktails eases her symptoms. One could imagine how, in a 6 week randomized trial, this “treatment” could be found efficacious and recommended for daily use and even prevention of symptoms. How her withdrawal symptoms after 10 years of daily compliance could lead those around her to believe that she “needed” the alcohol to correct an imbalance. This analogy is all too close to the truth.
Running With Broken Legs
Psychiatrist Dr. Daniel Carlat has said:
“And where there is a scientific vacuum, drug companies are happy to insert a marketing message and call it science. As a result, psychiatry has become a proving ground for outrageous manipulations of science in the service of profit.”
So, what happens when we let drug companies tell doctors what science is? We have an industry and a profession working together to maintain a house of cards theory in the face of contradictory evidence.
We have a global situation in which increases in prescribing are resulting in increases in severity of illness (including numbers and length of episodes) relative to those who have never been treated with medication.
To truly appreciate the breadth of evidence that states antidepressants are ineffective and unsafe, we have to get behind the walls that the pharmaceutical companies erect. We have to unearth unpublished data, data that they were hoping to keep in the dusty catacombs.
A now famous 2008 study in the New England Journal of Medicine by Turner et al sought to expose the extent of this data manipulation. They demonstrated that, from 1987 to 2004, 12 antidepressants were approved based on 74 studies. Thirty-eight were positive, and 37 of these were published. Thirty-six were negative (showing no benefit), and 3 of these were published as such while 11 were published with a positive spin(always read the data not the author’s conclusion!), and 22 were unpublished.
In 1998 tour de force, Dr. Irving Kirsch, an expert on the placebo effect, published a meta–analysis of 3,000 patients who were treated with antidepressants, psychotherapy, placebo, or no treatment and found that only 27% of the therapeutic response was attributable to the drug’s action.
This was followed up by a 2008 review, which invoked the Freedom of Information Act to obtain access to unpublished studies, finding that, when these were included, antidepressants outperformed placebo in only 20 of 46 trials (less than half!), and that the overall difference between drugs and placebos was 1.7 points on the 52 point Hamilton Scale. This small increment is clinically insignificant, and likely accounted for by medication side effects strategically employed (sedation or activation).
When active placebos were used, the Cochrane database found that differences between drugs and placebos disappeared, given credence to the assertion that inert placebos inflate perceived drug effects.
The finding of tremendous placebo effect in the treatment groups was also echoed in two different meta-analyses by Khan et al who found a 10% difference between placebo and antidepressant efficacy, and comparable suicide rates. The most recent trial examining the role of “expectancy” or belief in antidepressant effect, found that patients lost their perceived benefit if they believed that they might be getting a sugar pill even if they were continued on their formerly effective treatment dose of Prozac.
The largest, non-industry funded study, costing the public $35 million dollars, followed 4000 patients treated with Celexa (not blinded, so they knew what they were getting), and found that half of them improved at 8 weeks. Those that didn’t were switched to Wellbutrin, Effexor, or Zoloft OR “augmented” with Buspar or Wellbutrin.
Guess what? It didn’t matter what was done, because they remitted at the same unimpressive rate of 18-30% regardless with only 3% of patients in remission at 12 months.
How could it be that medications like Wellbutrin, which purportedly primarily disrupt dopamine signaling, and medications like Stablon which theoretically enhances the reuptake of serotonin, both work to resolve this underlying imbalance? Why would thyroid, benzodiazepines, beta blockers, and opiates also “work”? And what does depression have in common with panic disorder, phobias, OCD, eating disorders, and social anxiety that all of these diagnoses would warrant the same exact chemical fix?
As a holistic clinician, one of my bigger pet peeves is the use of amino acids and other nutraceuticals with “serotonin-boosting” claims. These integrative practitioners have taken a page from the allopathic playbook and are seeking to copy-cat what they perceive antidepressants to be doing.
The foundational “data” for the modern serotonin theory of mood utilizes tryptophan depletion methods which involve feeding volunteers amino acid mixtures without tryptophan and are rife with complicated interpretations.
Simply put, there has never been a study that demonstrates that this intervention causes mood changes in any patients who have not been treated with antidepressants.
In an important paper entitled Mechanism of acute tryptophan depletion: Is it only serotonin?, van Donkelaar et al caution clinicians and researchers about the interpretation of tryptophan research. They clarify that there are many potential effects of this methodology, stating:
“In general, several findings support the fact that depression may not be caused solely by an abnormality of 5-HT function, but more likely by a dysfunction of other systems or brain regions modulated by 5-HT or interacting with its dietary precursor. Similarly, the ATD method does not seem to challenge the 5-HT system per se, but rather triggers 5HT-mediated adverse events.”
So if we cannot confirm the role of serotonin in mood and we have good reason to believe that antidepressant effect is largely based on belief, then why are we trying to “boost serotonin”?
All you have to do is spend a few minutes on http://survivingantidepressants.org/or http://beyondmeds.com/ to appreciate that we have created a monster. Millions of men, women, and children the world over are suffering, without clinical guidance (because this is NOT a part of medical training) to discontinue psychiatric meds. I have been humbled, as a clinician who seeks to help these patients, by what these medications are capable of. Psychotropic withdrawal can make alcohol and heroin detox look like a breeze.
An important analysis by the former director of the NIMH makes claims that antidepressants “create perturbations in neurotransmitter functions” causing the body to compensate through a series of adaptations which occur after “chronic administration” leading to brains that function, after a few weeks, in a way that is “qualitatively as well as quantitatively different from the normal state.”
Changes in beta-adrenergic receptor density, serotonin autoreceptor sensitivity, and serotonin turnover all struggle to compensate for the assault of the medication.
Andrews, et al., calls this “oppositional tolerance,” and demonstrate through a careful meta-analysis of 46 studies demonstrating that patient’s risk of relapse is directly proportionate to how “perturbing” the medication is, and is always higher than placebo (44.6% vs 24.7%). They challenge the notion that findings of decreased relapse on continued medication represent anything other than drug-induced response to discontinuation of a substance to which the body has developed tolerance. They go a step further to add:
“For instance, in naturalistic studies, unmedicated patients have much shorter episodes, and better long-term prospects, than medicated patients. Several of these studies have found that the average duration of an untreated episode of major depression is 12–13 weeks.”
“Long-term antidepressant use may be depressogenic . . . it is possible that antidepressant agents modify the hardwiring of neuronal synapses (which) not only render antidepressants ineffective but also induce a resident, refractory depressive state.”
So, when your doctor says, “You see, look how sick you are, you shouldn’t have stopped that medication,” you should know that the data suggests that your symptoms are withdrawal, not relapse.
Longitudinal studies demonstrate poor functional outcomes for those treated with 60% of patients still meeting diagnostic criteria at one year (despite transient improvement within the first 3 months). When baseline severity is controlled for, two prospective studies support a worse outcome in those prescribed medication:
One in which the never-medicated group experienced a 62% improvement by six months, whereas the drug-treated patients experienced only a 33% reduction in symptoms, and another WHO study of depressed patients in 15 cities which found that, at the end of one year, those who weren’t exposed to psychotropic medications enjoyed much better “general health”; that their depressive symptoms were much milder”; and that they were less likely to still be “mentally ill.”
I’m not done yet. In a retrospective 10-year study in the Netherlands, 76% of those with unmedicated depression recovered without relapse relative to 50% of those treated.
Unlike the mess of contradictory studies around short-term effects, there are no comparable studies that show a better outcome in those prescribed antidepressants long term.
First Do No Harm
So, we have a half-baked theory in a vacuum of science that that pharmaceutical industry raced to fill. We have the illusion of short-term efficacy and assumptions about long-term safety. But are these medications actually killing people?
The answer is yes.
Unequivocally, antidepressants cause suicidal and homicidal behavior. The Russian Roulette of patients vulnerable to these “side effects” is only beginning to be elucidated and may have something to do with genetic variants around metabolism of these chemicals. Dr. David Healy has worked tirelessly to expose the data that implicates antidepressants in suicidality and violence, maintaining a database for reporting, writing, and lecturing about cases of medication-induced death that could make your soul wince.
What about our most vulnerable?
I have countless patients in my practice who report new onset of suicidal ideation within weeks of starting an antidepressant. In a population where there are only 2 randomized trials, I have grave concerns about postpartum women who are treated with antidepressants before more benign and effective interventions such as dietary modification and thyroid treatment. Hold your heart as you read through these reportsof women who took their own and their childrens’ lives while treated with medications.
Then there is the use of these medications in children as young as 2 years old. How did we ever get the idea that this was a safe and effective treatment for this demographic? Look no further than data like Study 329, which cost Glaxo Smith Klein 3 billion dollars for their efforts to promote antidepressants to children. These efforts required ghost-written and manipulated data that suppressed a signal of suicidality, falsely represented Paxil as outperforming placebo, and contributes to an irrepressible mountain of harmdone to our children by the field of psychiatry.
RIP Monoamine Theory
As Moncrieff and Cohen so succinctly state:
“Our analysis indicates that there are no specific antidepressant drugs, that most of the short-term effects of antidepressants are shared by many other drugs, and that long-term drug treatment with antidepressants or any other drugs has not been shown to lead to long-term elevation of mood. We suggest that the term “antidepressant” should be abandoned.”
So, where do we turn?
The field of psychoneuroimmunology dominates the research as an iconic example of how medicine must surpass its own simplistic boundaries if we are going to begin to chip away at the some 50% of Americans who will struggle with mood symptoms, 11% of whom will be medicated for it.
There are times in our evolution as a cultural species when we need to unlearn what we think we know. We have to move out of the comfort of certainty and into the freeing light of uncertainty. It is from this space of acknowledged unknowing that we can truly grow. From my vantage point, this growth will encompass a sense of wonder – both a curiosity about what symptoms of mental illness may be telling us about our physiology and spirit, as well as a sense of humbled awe at all that we do not yet have the tools to appreciate. For this reason, honoring our co-evolution with the natural world, and sending the body a signal of safety through movement, diet, meditation, and environmental detoxification represents our most primal and most powerful tool for healing.
Learn more by taking Dr. Kelly Brogan’s E-Course Vital Mind Reset.
GreenMedInfo LLC. . This work is reproduced and distributed with the permission of GreenMedInfo LLC. Where it first originally appeared. Want to learn more from GreenMedInfo? Sign up for the newsletter here http://www.greenmedinfo.com/greenmed/newsletter.”
Dr. Brogan is boarded in Psychiatry/Psychosomatic Medicine/Reproductive Psychiatry and Integrative Holistic Medicine, and practices Functional Medicine, a root-cause approach to illness as a manifestation of multiple-interrelated systems. After studying Cognitive Neuroscience at M.I.T., and receiving her M.D. from Cornell University, she completed her residency and fellowship at Bellevue/NYU. She is one of the nation’s only physicians with perinatal psychiatric training who takes a holistic evidence-based approach in the care of patients with a focus on environmental medicine and nutrition. She is also a mom of two, and an active supporter of women’s birth experience. She is the Medical Director for Fearless Parent, and an advisory board member for GreenMedInfo.com. Visit her website.
Russian Military Colonel Publishes An Article Claiming Human & Animal Telepathy Is 100 Percent Real
- The Facts:The Russian Ministry of Defense published an article about the existence of military parapsychology in Russian military techniques, with which you can penetrate into the thoughts of the enemy, hack computer programs, and communicate telepathically.
- Reflect On:Why is this type of science studied at the highest levels of various governments, yet ridiculed and not studied at all within the mainstream?
Is telepathy real? It’s hard to argue against it; in fact, I would say that it’s not really up for debate. That being said, when it comes to topics like these, the field is polluted with a bad reputation given its association with magic, superstition and ‘pseudoscience,’ terms that often come from those who condemn the subject without ever really looking into it. The evidence for the existence of telepathy is actually quite overwhelming, and in many cases, much stronger than most other areas of science.
Dr. Jessica Utts is a great person to bring up, as I’ve done many times before, to hammer this fact home. She is the Chair of the Department of Statistics at the University of California, Irvine. In 1999, she published a paper showing how the statistical significance with regards to results seen from studies under the realm of parapsychology (telepathy, remote viewing, etc) are stronger than some of the studies used to approve some medications. In a recent interview, she emphasized the following.
“What convinced me was just the evidence, the accumulating evidence as I worked in this field and I got to see more and more of the evidence. I visited the laboratories, even beyond where I was working to see what they were doing and I could see that they had really tight controls… and so I got convinced by the good science that I saw being done. And in fact I will say as a statistician I’ve consulted in a lot of different areas of science; the methodology and the controls on these experiments are much tighter than any other area of of science where I’ve worked.” (source)
Why is it that these topics are not touched by mainstream academia, yet studied at the highest levels of government? Multiple governments all over the world have been studying this phenomenon for decades, and a lot has been declassified. Take the remote viewing program that was conducted by the US government/CIA and Stanford University, for example.
After its declassification in 1995, or at least its partial declassification, the Department of Defense and those involved revealed an exceptionally high success rate.
To summarize, over the years, the back-and-forth criticism of protocols, refinement of methods, and successful replication of this type of remote viewing in independent laboratories has yielded considerable scientific evidence for the reality of the [remote viewing] phenomenon. (source)
The latest example comes from Russia, as their Ministry of Defence recently published an article about the existence and study of parapsychology within the Russian military. The article explains how these techniques are and were used to penetrate the thoughts of the enemy (mind-reading) as well as to hack into enemy computer systems. The article is titled “Super Soldier for the Future Wars” and was published in the Defense Army magazine.
The article was written by Colonel Nikolai Poroskov, who explained that they use parapsychological techniques like telepathy for combat purposes, revealing secrets, disclosing locations, etc… He even discloses that Russian specialists have learned telepathy by working with dolphins.
As a note to readers, we here at Collective Evolution do not condone the use of animals for any type of experimentation. There is no information on the conditions of these experiments, but we are assuming they were captured for military purposes, which is extremely sad and heart-breaking.
“They mentally gave the animals the commands that they carried out. Similar practiced by the famous trainer Durov. The technique, as it turned out, is applicable to humans. Moreover, the impact was even possible on the technique. With an effort of thought you can, for example, shoot down computer programs, burn crystals in generators, eavesdrop on a conversation, or break television and radio broadcasts and communications. Good luck ended with such experiments as reading a document lying in a safe, even if it is in a foreign language that we do not speak; identification of individuals belonging to the terrorist network; identifying potential candidates for terrorist groups,” the statement reads. (source)
Quite astonishing, isn’t it? Parapsychology seems to be the largest known threat to any type of secrecy, doesn’t it? I found the reference to hacking computers quite interesting. Can telepathy really be used for purposes like hacking electronic equipment? I did some more digging and found an interesting document inside of the CIA’s electronic reading room with regards to the Soviet Union.
Here’s a quote from the document:
The Soviet Union is well aware of the benefits and applications of parapsychology research. In 1963, a Kremilin edict apparently gave top priority to biological research, which in Russia includes parapsychology. The major impetus behind the Soviet drive to harness the possible capabilities of telepathic communication, telekinetics, and bionics is said to come from the Soviet military and the KGB. Today it is reported that the USSR has twenty or more centres for the study of parapsychological phenomena, with an annual budget estimated in 1967 at over 13 million dollars and reported to be as high as 21 million dollars.
Today, we know that trillions of dollars have gone into black budget programs in the United States, many of which likely deal with parapsychology, as they have in the past.
The document also states:
There are reports that the Soviets are training their cosmonauts in telepathy to back-up their electronic equipment while in outer space. One of these back-up schemes is known to involve coded telepathic messages. This method was previously demonstrated in March 1967, when a coded telepathic message was flashed from Moscow to Leningrad. The involvement of astronauts or cosmonauts in telepathy experiments is not necessarily unprecedented. In February 1971, during the Apollo 14 flight to the moon, astronaut Edgar Mitchell made 150 separate attempts to project his thoughts from inside the space capsule back to an individual on earth. The results of the Apollo 14 experiments have been well-documented in detail and are published in the Journal of Parapsychology. (source)
Deeper Black Budget Discussion On CETV
Again, these programs lie within the realm of the black budget and are highly classified. Who knows how far ahead of the mainstream world they truly are?
CETV is a platform we created in order to combat the censorship and demonetization we have been facing over the past few years. On episode 4 of The Collective Evolution Show on CETV, we discussed the black budget in much greater detail. Below is a clip exploring the missing money from the black budget and special access programs, explaining where the money is going and what exactly it’s being used for.
You can become a member of CETV, get access to the full show and many others, and support conscious media here.
Human consciousness and parapsychology should not only be studied for the purposes of learning new defence tactics. Humans have great potential, and there is still so much that we have yet to discover about ourselves. What needs to change is the intention behind these discoveries.
Magnesium Puts Psychiatric Drugs to Shame for Depression
(Sayer Ji) A powerful clinical study shows that pennies worth of magnesium a day provides an effective, safe, affordable alternative to dangerous and relatively ineffective pharmaceutical antidepressants.
Depression is one of the most widely diagnosed conditions of our time, with over 3 million cases in the U.S. every year, and 350 million believed affected worldwide.1 Conventional medicine considers antidepressant drugs first-line treatments, including the newly approved injected postpartum drug costing $34,000 a treatment, to the tune of a 16 billion dollars in global sales by 2023. Despite their widespread use, these drugs are fraught with a battery of serious side effects, including suicidal ideation and completion — the last two things you would hope to see in a condition that already has suicidality as a co-morbidity. For this reason alone, natural, safe, and effective alternatives are needed more than ever before.
While research into natural alternatives for depression is growing daily — GreenMedInfo.com’s Depression database contains 647 studies on over 100 natural substances that have been studied to prevent or treat depression — it is rare to find quality human clinical research on the topic published in well-respected journals. That’s why a powerful study published in PLOS One titled, “Role of magnesium supplementation in the treatment of depression: A randomized clinical trial,” is so promising. Not only is magnesium safe, affordable, and easily accessible, but according to this recent study, effective in treating mild-to moderate symptoms of depression.
While previous studies have looked at the association between magnesium and depression,2-7 this is the first placebo-controlled clinical study to evaluate whether the use of over-the-counter magnesium chloride (248 mg elemental magnesium a day for 6 weeks) improves symptoms of depression.
The study design was a follows:
“ An open-label, blocked, randomized, cross-over trial was carried out in outpatient primary care clinics on 126 adults (mean age 52; 38% male) diagnosed with and currently experiencing mild-to-moderate symptoms with Patient Health Questionnaire-9 (PHQ-9) scores of 5–19. The intervention was 6 weeks of active treatment (248 mg of elemental magnesium per day) compared to 6 weeks of control (no treatment). Assessments of depression symptoms were completed at bi-weekly phone calls. The primary outcome was the net difference in the change in depression symptoms from baseline to the end of each treatment period. Secondary outcomes included changes in anxiety symptoms as well as adherence to the supplement regimen, appearance of adverse effects, and intention to use magnesium supplements in the future. Between June 2015 and May 2016, 112 participants provided analyzable data.”
The study results were as follows:
“Consumption of magnesium chloride for 6 weeks resulted in a clinically significant net improvement in PHQ-9 scores of -6.0 points (CI -7.9, -4.2; P<0.001) and net improvement in Generalized Anxiety Disorders-7 scores of -4.5 points (CI -6.6, -2.4; P<0.001). Average adherence was 83% by pill count. The supplements were well tolerated and 61% of participants reported they would use magnesium in the future. Similar effects were observed regardless of age, gender, baseline severity of depression, baseline magnesium level, or use of antidepressant treatments. Effects were observed within two weeks. Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”
For perspective, conventional antidepressant drugs are considering to generate an “adequate or complete treatment response” with a PHQ-9 score “decrease of 5 points or more from baseline.” At this level of efficacy, their recommended action is: “Do not change treatment; conduct periodic follow-up.” The magnesium’s score of -6.0 therefore represents the height of success within conventional expectations for a complete response, which is sometimes termed “remission.” In contradistinction, conventional antidepressant drugs result in nearly half of patients discontinuing treatment during the first month, usually due to their powerful and sometimes debilitating side effects.8
To summarize the main study outcomes:
- There was a clinically significant improvement in both Depression and Anxiety scores.
- 61% of patients reported they would use magnesium in the future.
- Similar effects occurred across age, gender, severity of depression, baseline magnesium levels, or use of antidepressant treatments.
- Effects were observed within two weeks.
The study authors concluded:
“Magnesium is effective for mild-to-moderate depression in adults. It works quickly and is well tolerated without the need for close monitoring for toxicity.”
Beyond Depression: Magnesium’s Many Health Benefits and Where To Source It
Magnesium is a central player in your body’s energy production, as its found within 300 enzymes in the human body, including within the biologically active form of ATP known as MG-ATP. In fact, there have been over 3,751 magnesium binding sites identified within human proteins, indicating that it’s central nutritional importance has been greatly underappreciated.
Research relevant to magnesium has been accumulating for the past 40 years at a steady rate of approximately 2,000 new studies a year. Our database project has indexed well over 100 health benefits of magnesium thus far. For the sake of brevity, we will address seven key therapeutic applications for magnesium as follows:
- Fibromyalgia: Not only is magnesium deficiency common in those diagnosed with fibromyalgia, 9,10 but relatively low doses of magnesium (50 mg), combined with malic acid in the form of magnesium malate, has been clinically demonstrated to improve pain and tenderness in those to which it was administered.11
- Atrial Fibrillation: A number of studies now exist showing that magnesium supplementation reduce atrial fibrillation, either by itself, or in combination with conventional drug agents.12
- Diabetes, Type 2: Magnesium deficiency is common in type 2 diabetics, at an incidence of 13.5 to 47.7% according to a 2007 study. 13 Research has also shown that type 2 diabetics with peripheral neuropathy and coronary artery disease have lower intracellular magnesium levels. 14 Oral magnesium supplementation has been shown to reduce plasma fasting glucose and raising HDL cholesterol in patients with type 2 diabetes.15 It has also been shown to improve insulin sensitivity and metabolic control in type 2 diabetic subjects.16
- Premenstrual Syndrome: Magnesium deficiency has been observed in women affected by premenstrual syndrome.17 It is no surprise therefore that it has been found to alleviate premenstrual symptoms of fluid retention, 18 as well as broadly reducing associated symptoms by approximately 34% in women, aged 18-45, given 250 mg tablets for a 3-month observational period.20 When combined with B6, magnesium supplementation has been found to improve anxiety-related premenstrual symptoms.19
- Cardiovascular Disease and Mortality: Low serum magnesium concentrations predict cardiovascular and all-cause mortality.21 There are a wide range of ways that magnesium may confer its protective effects. It may act like a calcium channel blocker,22it is hypotensive,23 it is antispasmodic (which may protect against coronary artery spasm),24 and anti-thrombotic.25 Also, the heart muscle cells are exceedingly dense in mitochondria (as high as 100 times more per cell than skeletal muscle), the “powerhouses” of the cell,” which require adequate magnesium to produce ATP via the citric acid cycle.
- Migraine Disorders: Blood magnesium levels have been found to be significantly lower in those who suffer from migraine attacks.26,27 A recent Journal of Neural Transmission article titled, “Why all migraine patients should be treated with magnesium,” pointed out that routine blood tests do not accurately convey the true body magnesium stores since less than 2% is in the measurable, extracellular space, “67% is in the bone and 31% is located intracellularly.”28The authors argued that since “routine blood tests are not indicative of magnesium status, empiric treatment with at least oral magnesium is warranted in all migraine sufferers.” Indeed, oral magnesium supplementation has been found to reduce the number of headache days in children experiencing frequent migranous headaches,29and when combined with l-carnitine, is effective at reducing migraine frequency in adults, as well.30
- Aging: While natural aging is a healthy process, accelerated aging has been noted to be a feature of magnesium deficiency,31especially evident in the context of long space-flight missions where low magnesium levels are associated with cardiovascular aging over 10 times faster than occurs on earth.32 Magnesium supplementation has been shown to reverse age-related neuroendocrine and sleep EEG changes in humans.33 One of the possible mechanisms behind magnesium deficiency associated aging is that magnesium is needed to stabilize DNA and promotes DNA replication. It is also involved in healing up of the ends of the chromosomes after they are divided in mitosis.34
It is quite amazing to consider the afformentioned side benefits of magnesium consumption or supplementation within the context of the well-known side effects of pharmaceutical approaches to symptom management of disease. On average, conventional drugs have 75 side effects associated with their use, including lethal ones (albeit sometimes rare). When considering magnesium’s many side benefits and extremely low toxicity, clearly this fundamental mineral intervention (and dietary requirement) puts pharmaceutical approaches to depression to shame.
Best Sources of Magnesium In The Diet
The best source of magnesium is from food, and one way to identify magnesium-containing foods are those which are green, i.e. chlorophyll rich. Chlorophyll, which enable plants to capture solar energy and convert it into metabolic energy, has a magnesium atom at its center. Without magnesium, in fact, plants could not utilize the sun’s light energy.
Magnesium, however, in its elemental form is colorless, and many foods that are not green contain it as well. The point is that when found complexed with food cofactors, it is absorbed and utilized more efficiently than in its elemental form, say, extracted from limestone in the form of magnesium oxide.
The following foods contain exceptionally high amounts of magnesium. The portions described are 100 grams, or a little over three ounces.
- Rice bran, crude (781 mg)
- Seaweed, agar, dried (770 mg)
- Chives, freeze-dried (640 mg)
- Spice, coriander leaf, dried (694 mg)
- Seeds, pumpkin, dried (535 mg)
- Cocoa, dry powder, unsweetened (499 mg)
- Spices, basil, dried (422 mg)
- Seeds, flaxseed (392 mg)
- Spices, cumin seed (366 mg)
- Nuts, brazilnuts, dried (376 mg)
- Parsley, freeze-dried (372 mg)
- Seeds, sesame meal (346 mg)
- Nut, almond butter (303 mg)
- Nuts, cashew nuts, roasted (273 mg)
- Soy flour, defatted (290 mg)
- Whey, sweet, dried (176 mg)
- Bananas, dehydrated (108 mg)
- Millet, puffed (106 mg)
- Shallots, freeze-dried (104 mg)
- Leeks, freeze-dried (156 mg)
- Fish, salmon, raw (95 mg)
- Onions, dehydrated flakes (92 mg)
- Kale, scotch, raw (88 mg)
Fortunately, for those who need higher doses, or are not inclined to consume magnesium rich foods, there are supplemental forms commonly available on the market. Keep in mind, for those who wish to take advantage of the side benefit of magnesium therapy, namely, its stool softening and laxative properties, magnesium citrate or oxide will provide this additional feature.
For those looking to maximize absorption and bioavailability magnesium glycinate is ideal, as glycine is the smallest amino acid commonly found chelated to magnesium, and therefore highly absorbable.
Mandela Effect – Analysis of a Worldwide Phenomenon
ANNOUNCING PUBLICATION OF NEW MANDELA EFFECT BOOK by TS Caladan
After months of researching the Mandela Effect, which consisted of reading about it online, talking to people, but mainly viewing THOUSANDS of YouTube videos…
I’ve changed (excuse the pun). I’ve went from skeptic to non-skeptic in time, under the weight of evidence. If the masses feel comfortable in believing Mandela is only miss-remembering, mistaken memories by a lot of unclear people, then let them. You’ll never convince born-skeptics…because they won’t look into it. Why would they bother, waste their time, when they already know what this new craze, so-called “phenomenon” is and can easily explain it?
The masses (sometimes not the majority) can only see it differently: they are under a Black Magic spell. Yet. Every Mandela cynic and debunker can point to the “facts,” the “stats,” the histories and what’s right in front of us as “proof” that we of the Mandela Community are wrong or crazy or stupid.
Doesn’t feel good being told: “You’re wrong!” or confused, now, does it? Maybe we shouldn’t demand/insist one way or the other? Who really has the mistaken memories or the mistaken view of reality? “Who is seeing and believing the illusion?” is an intriguing question.
Basically, there are two kinds of people: 1) Those that believe there’s magic in the world. 2) Those that are confident there is no magic in the world. Or, those that think a blade of grass can unnaturally be made to change and others who are sure that it is impossible. We believe what has FOUNDATION to us, what seems sensible and toss away “absurdities” into the Fantasy Bin. Maybe we have the wrong Foundations? The wrong, narrow education? Possibly. To understand the truth or what’s really going on…
You need lessons in Science “Fiction”? It’s not fantasy. Predictive Programming. Elites, who control our Media and “entertainment,” have been telling us about what they’ve planned (Mandela) for a long time. Some of us are only realizing this now. Maybe our fundamental education and experiences should have included SF stories that inspired us to fly in dreams, to the furthest reaches of the Imagination? Outer Limits? Twilight Zones? That is, if you wanted to create, innovate, invent, mature or progress technically, mentally and spiritually? Grow and extend yourself outside of boxes, limits? To know or discover truth…we have to see beyond, beyond the surface of things in front of our eyes. It’s always been that way, long before the Mandela Wave struck 5 years ago and pushed the world and us to the Dark Side, virtually overnight. Maybe they’re doing this via technology they’ve kept from us, perverted Tesla Technology (they’ve done before)?
The sharp, clear message of ‘Mandela Effect – analysis of a worldwide phenomenon‘ is an extraordinary, other-worldly explanation, beyond mistaken memories. An incredible transformation has occurred to our physical universe. What is even more incomprehensible is the fact that relatively few people would believe it, relatively few can see the changes and are certain: “It’s always been that way.” Not so fast.
I was sure the original Mandela was not a true Mandela Effect, but only at first, before I examined what the Effect was. Because…we all know history, right? We all know the story of Nelson Mandela: imprisoned by South African government in the ’80s, then released and became a world hero and President of the country that had imprisoned him. A wide spectrum of oddities has made me alter my stance. Now I’m sure at least one parallel world has been made to intersect with the Old World we all knew, like a ‘Reboot’ game has descended upon us and changed our world and many people in it.
But not to everyone. Possibly, in the other reality, people distinctly remember Nelson Mandela dying in prison because he did die in prison? An alternate reality. Maybe?
The Mandela Community isn’t a collection of weirdos with mistaken memories. Because they remember just about the same universe, the same other world where C3P0 was always all-gold, there was always Jiffy and never JIF, Ed McMahon worked for Publisher’s Clearing House, and on and on it goes. Berenstain Bears were Jewish and “the” was Smokey Bear’s middle name. It was always ‘Looney Toons,’ but now it was always ‘Looney Tunes’? M.E. people have good memories.
Far from all the Mandela YT items online are real and true. Some ARE stupidity and ignorance, such as “Crosby, Stills and Nash” now have a new member: Neil Young! No, that’s the Village People and the Jacksons. Or, now, there are “hats” on Easter Island statues, when truth is: It was always one row of them and not every stone giant. Uranus and Neptune always had faint rings, it simply wasn’t common knowledge. False rumors and misconceptions are not true Mandelas. Bogie never said, “Play it again, Sam.” Captain Kirk never said, “Beam me up, Scotty.” This is trivia and not Mandelas.
Why do millions of people remember South America 1000 miles west from where it is today and Panama Canal went west to east, not more north and south? RESIDUE evidence exists of that other world, our lost Old World, where Costa Rica and Gibraltar were islands. But not today. They’ve been “magically” attached to the mainland. This baffles many who knew it and experienced it differently.
Products have inexplicably changed their designs and NAMES! They would never name-change for no good reason. They build brands over decades. These are not product upgrades or normal changes over time.
We could be wrong and mistaken of small, obscure things, but not famous lines in movies and well-known songs. So much has altered and a New World, a Dark-Universe is now upon us, as if we’ve switched with our negative counterparts, such as we’ve seen in Star Trek’s “Mirror” universe or almost every movie, series (‘Stranger Things,’ etc.).
My new book is a collection of the best examples of the Mandela Wave and global changes that will defy and discombobulate any skeptic. Even our bodies have changed from what they were, so said doctors and nurses. False Mandelas have definitely been “thrown into the Bullshit Bin.” Weeded out. The book includes the classic contradictions, paradoxes, their descriptions and analysis, somewhat like ‘Ripley’s Believe It or Not’ books. Also there’s many new discoveries you’ve never heard previously.
I found answers. It was highly unexpected.
I discovered evidence on my own to answer:
WHO IS DOING THIS TO US? I think I know WHY. I am not sure HOW, there are many theories on that point. But I believe I’ve followed the evidence and know the answer to a very important question: WHEN? When did the Mandela Wave strike and warp our more-positive world into its negative counterpart? ‘Tidy Cat’ to ‘Tidy Cats.’
Five years ago. Read how I came to that conclusion. I believe that was when Mars, the Moon, ancient and recent monuments, paintings, changed, when the Great Pyramid “magically” switched places with Khefren and was suddenly closer to Cairo! When the Statue of Liberty moved off Ellis Island and re-positioned itself on Liberty Island.
The shocker to any student of the Mandela Effect is a realization that this explains:
- Why are there suddenly giant statues on Earth now that very few remember? New ancient ruins on land and under the sea?
- Why are there gigantic Jesus statues and their complete histories few people are familiar with?
- New islands, cities, countries have appeared and their full histories? Yet, again, this is news to a large number of people.
- Land changes, unnatural/geographical changes reported over and over by natives of those nations. They know their own country and have repeatedly said borders, etc., are not the same as what they were only a few years ago.
- Why do U.S. state borders also appear different to a portion of the population? Two Michigans? Minnesota with a “spike” into Canada? Not to a lot of people.
- So much has simply materialized, and only has been known to exist in the last 5 years. The “Flying Saucer” Cetiya Temple with 300,000 golden Buddhas that’s stood in Thailand for 50 years? Or entire Tartarian Age, now, according to old maps and amazing early photos that stun about everybody! Advanced building techniques in Civil War times? Tesla tech in architecture long before Tesla? It’s absolute bullshit. Or I should say: Mud-Floods and historical “re-sets” and phenomenal photos no one remembers did not exist in our Old Reality! There the maps are and unbelievable photography and films BEFORE there should have been such photography and films. Phenomenal old cities, (Tartary) empires, that never previously existed, yet there they are. This is a new ancient past and recent past that have been placed over everything, like a New Skin.
Believe it or not.
If you have a strong memory associated with a lost reality of the Old World, that’s been “burned into your brain,” nothing in the universe is going to tell you: you are wrong or crazy or mistaken. If Jiffy, and not Skippy, was your favorite, you know it existed.
I was scolded as a child and told: “Remember the 4th Commandment. Honor thy mother and father,” by my parents. They weren’t wrong or mistaken. The Parent-Commandment was fourth. Now by all records, today, it’s fifth. Guess it’s not that important to obey parents, anymore?
I know for a fact Secondo Pia was commissioned by the Pope to first photograph the Shroud of Turin in 1902. I’ve talked about it enough and even mentioned my accurate facts on at least one radio show. But, gee, if you checked the new “facts,” the date was 1898 (along with more advanced photography).
The Challenger disaster could not have happened in January of 1986, as records say today. I have vivid memories discussing it with a person who was out of my life a year earlier. I’m not mistaken. This perfectly jives with kids who saw it in class, and they remember it happened before that date. Exactly like my experience.
I know the Moon has drastically changed. “Man in the Moon” appearance is now gone. “Lady of the Moon” in profile was always there, but she was more northeast, up and away. Today, she’s front and center, right in the middle of the Moon. Old records, old movies, documentaries, tell us it’s always been that way. Mandela people who remember, know it’s not true, even though all the physical evidence reports it’s true.
One more Warrior Woman has suddenly come to be; she stands atop DC’s Capitol building. We’re supposed to believe Thomas Crawford created this 20′ bronze woman with sword, shield, helmet, and it’s stood there over this famous building since 1863?! At the height of chauvinism, a woman symbolized a soldier? No way. Why is this new to so many? There she stands in old films like ‘Day the Earth Stood Still’ or anytime D.C. was invaded. It was a flag. Also, there’s the Lincoln Memorial. Abe never made a fist before, but there it is in reality and in black and white newsreels, etc.
All the true Mandelas are connected and I believe can be traced to ENGLAND (CERN, other portals, etc.) and back to the end of 2015. It probably happened in waves. But something quite, bloody extraordinary occurred. There wouldn’t be millions of “mistaken people” and conflicts in every department. Suddenly. Never before has there ever been a memory-clash to such a mass-scale! If BS: There wouldn’t be a consistency in the Other World, that’s been gone/lost for years now, and slowly fades away from memory. A new high-tech method to send us to war and cause even more chaos in the global empire? A nasty machine that performs Harry Potter wizardry?
There isn’t much I agree with religious fundamentalists; I’m a scientist to their 17th Century views. But they know their Bibles. There is no doubt. There is no debate or Mandela question in any corner of the Church. They KNOW the King James has changed! Investigate! The KJV Bible was published in 1612. Now, it’s changed to the “Prince James” Bible, published in 1611. Queen Elizabeth, before Genesis, is praised in the intro, which is impossible. Even if the mega-praise was meant for Elizabeth the First, not Second, she had nothing to do with the English translation. She died and James of Scotland became King. He was never Prince James. Today. There are all the PJV Bibles. Now they have become Dark Bibles of such perversion and “Devil-Speak.” Investigate~
Now Moses is displayed in old sculptures and paintings with HORNS? Didn’t you know God’s bare butt has been on the Sistine ceiling for 500 years? [Exodus 33:23]. What was Michelangelo thinking? No, it hasn’t. Just appeared…
If you’ve examined the “mountain” of Mandela evidence and still maintain: Nothing strange is going on, that’s your choice. The very least you might have to consider, if we are not inside a holographic TRON game and losing: We seem to be in a M. Knight Shyamalan movie, because huge numbers of the world’s population have recently been BIRDBOXED, supremely.
Question remains: Are we seeing the environment that always was, or a new reality, an illusion and fabrication of what was real? Here and there, it’s different. Glitches in the Matrix?
I was the biggest opponent of the “Flat-Earth” idea, presently, and in any passed life. But. I’ve gone through a change in thought: It might not be a Flat-Earth…
It might be a whole new universe that’s flat? Digital? A Flat-Universe. Maybe?
Look at the clues. See if anything makes sense these days: Why are jets now mounted on wings like headlights and have never been securely fastened under wings? Never been Chevy Camero, always been Camaro? Question things; search memories. Anything in the Old (Mandela) World familiar to you? But mainly: let’s stay positive. Don’t switch to your negative polarity, or your evil twin. Good behaviors, not bad.
Study the Mandela Effect, openly. See how product names you think, and still think, are spelled one way, are really spelled completely different than what you had thought. You’re not wrong. There’s been some odd, real changes to our world. It was mad and crazy before. We had no idea of truth, real history, science, and so much more…
We’ll never know now.
“DEDICATED TO THE OLD WORLD, that should never be forgotten.”
Find out how to get a copy of ‘MANDELA EFFECT – analysis of a worldwide phenomenon.’ Published by TWB Press in Colorado. Signed, numbered copies will be available very soon by the author (free shipping).
Contact Tray: [email protected]
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