Connect with us

Science & Technology

Government Report Offers MORE Evidence Cannabis is a Wonder Drug for Cancer and Good Health

Government Report Offers MORE Evidence Cannabis is a Wonder Drug for Cancer and Good Health 88

As the world’s most beloved herb, Cannabis, continues to be liberated from the persecution of the government and the pharmaceutical-industrial complex, research continues to validate the many health benefits of Cannabis. This time, The National Cancer Institute, a government-funded organization has released a report indicating that cannabis and cannabinoids are indeed powerful agents of good health and wonderful supplements in the fight against cancer.The report begins with an important summary of the history of Cannabis:

Cannabis use for medicinal purposes dates back at least 3,000 years.[15] It was introduced into Western medicine in the 1840s by W.B. O’Shaughnessy, a surgeon who learned of its medicinal properties while working in India for the British East Indies Company. Its use was promoted for reported analgesic, sedative, anti-inflammatory, antispasmodic, and anticonvulsant effects.

Government Report Offers MORE Evidence Cannabis is a Wonder Drug for Cancer and Good Health 89

In 1937, the U.S. Treasury Department introduced the Marihuana Tax Act. This Act imposed a levy of $1 per ounce for medicinal use of Cannabis and $100 per ounce for recreational use. Physicians in the United States were the principal opponents of the Act. The American Medical Association (AMA) opposed the Act because physicians were required to pay a special tax for prescribing Cannabis, use special order forms to procure it, and keep special records concerning its professional use. In addition, the AMA believed that objective evidence that Cannabis was harmful was lacking and that passage of the Act would impede further research into its medicinal worth.[6] In 1942, Cannabis was removed from the U.S. Pharmacopoeia because of persistent concerns about its potential to cause harm.[2,3]

In 1951, Congress passed the Boggs Act, which for the first time, included Cannabis with narcoticdrugs. In 1970, with the passage of the Controlled Substances Act, marijuana was classified as a Schedule I drug. Drugs in this category are distinguished as having no accepted medicinal use. Other Schedule I substances include heroin, LSD, mescaline, methaqualone, and gamma-hydroxybutyrate.

Despite its designation as having no medicinal use, Cannabis was distributed to patients by the U.S. government on a case-by-case basis under the Compassionate UseInvestigational New Drug program established in 1978. Distribution of Cannabis through this program was discontinued in 1992.[14] Although federal law prohibits the use of Cannabis, the table below lists the localities that permit its use for certain medical conditions.

The main psychoactive constituent of Cannabis was identified as delta-9-tetrahydrocannabinol (THC). In 1986, synthetic delta-9-THC in sesame oil was licensed and approved for the treatment of chemotherapy-associated nausea and vomiting under the generic name dronabinol. Clinical trials determined that dronabinol was as effective as or better than other antiemetic agents available at the time.[7] Dronabinol was also studied for its ability to stimulate weight gain in patients with AIDS in the late 1980s. Thus, the indications were expanded to include treatment of anorexia associated with human immunodeficiency virus infection in 1992. Clinical trial results showed no statistically significant weight gain, although patients reported an improvement in appetite.[8,9]

Within the past 20 years, the neurobiology of cannabinoids has been analyzed.[1013] The first cannabinoid receptor, CB1, was identified in the brain in 1988. A second cannabinoid receptor, CB2, was identified in 1993. The highest concentration of CB2 receptors is located on B lymphocytes and natural killer cells, suggesting a possible role in immunity. Endogenous cannabinoids (endocannabinoids) have been identified and appear to have a role in pain modulation, control of movement, feeding behavior, and memory.[11]

The effective chemical agents in cannabis that is being isolated for research are then described in this report:

Cannabinoids are a group of 21-carbon–containing terpenophenolic compounds produced uniquely by Cannabis sativa and Cannabis indica species.[1,2] These plant-derived compounds may be referred to as phytocannabinoids. Although delta-9-tetrahydrocannabinol (THC) is the primary psychoactive ingredient, other known compounds with biologic activity are cannabinol, cannabidiol (CBD), cannabichromene, cannabigerol, tetrahydrocannabivarin, and delta-8-THC. CBD, in particular, is thought to have significant analgesic and anti-inflammatory activity without the psychoactive effect (high) of delta-9-THC.”

The report then goes on to outline several key potential benefits of cannabis that should be noted in the race for a cure for cancer, and also in the debate to further legalize cannabis in the United States.

Cannabis protects against cancer:

One study in mice and rats suggested that cannabinoids may have a protective effect against the development of certain types of tumors.” They continue; “Cannabinoids may cause antitumor effects by various mechanisms, including induction of cell death, inhibition of cell growth, and inhibition of tumor angiogenesis invasion and metastasis. One review summarizes the molecular mechanisms of action of cannabinoids as antitumor agents. Cannabinoids appear to kill tumor cells but do not affect their nontransformed counterparts and may even protect them from cell death.

Cannabis targets and kills lung cancer and breast cancer cells:

“An in vitro study of the effect of CBD on programmed cell death in breast cancer cell lines found that CBD induced programmed cell death, independent of the CB1, CB2, or vanilloid receptors. CBD inhibited the survival of both estrogen receptor–positive and estrogen receptor–negative breast cancer cell lines, inducing apoptosis in a concentration-dependent manner while having little effect on nontumorigenic, mammary cells.”

Cannabis has anti-inflammatory effects and may be beneficial for the treatment of colon cancer:

“In addition, both plant-derived and endogenous cannabinoids have been studied for anti-inflammatory effects. A mouse study demonstrated that endogenous cannabinoid system signaling is likely to provide intrinsic protection against colonic inflammation.[23] As a result, a hypothesis that phytocannabinoids and endocannabinoids may be useful in the risk reduction and treatment of colorectal cancer has been developed.[2427]“

Cannabinoids may assist in the uptake of other cancer drugs, increasing their effectiveness:

“CBD may also enhance uptake of cytotoxic drugs into malignant cells. Activation of the transient receptor potential vanilloid type 2 (TRPV2) has been shown to inhibit proliferation of human glioblastoma multiforme cells and overcome resistance to the chemotherapy agent carmustine.[28] In an in vitro model, CBD increased TRPV2 activation and increased uptake of cytotoxic drugs, leading to apoptosis of glioma cells without affecting normal human astrocytes. This suggests that coadministration of CBD with cytotoxic agents may increase drug uptake and potentiate cell death in human glioma cells.”

Cannabis stimulates appetite:

“Many animal studies have previously demonstrated that delta-9-THC and other cannabinoids have a stimulatory effect on appetite and increase food intake. It is believed that the endogenous cannabinoid system may serve as a regulator of feeding behavior. The endogenous cannabinoid anandamide potently enhances appetite in mice.[29] Moreover, CB1 receptors in the hypothalamus may be involved in the motivational or reward aspects of eating.[30]“

Cannabis is an effective analgesic and pain medication:

“Cannabinoids may also contribute to pain modulation through an anti-inflammatory mechanism; a CB2 effect with cannabinoids acting on mast cell receptors to attenuate the release of inflammatory agents, such as histamine and serotonin, and on keratinocytes to enhance the release of analgesic opioids has been described.[3436] One study reported that the efficacy of synthetic CB1- and CB2-receptor agonists were comparable with the efficacy of morphine in a murine model of tumor pain.[37]“

After presenting this important information the report then goes on to discuss the pharmacology of cannabis, a summary of clinical research on cannabis, and even the negative effects of it’s consumption, which do include a risk of cancer, although this is rather inconclusive.

As the report states, “cannabis has been used for medicinal purposes for thousands of years,” and only recently has it been targeted for prohibition.

At a time when cancer is now the leading cause of death of children and cancer rates are climbing for everyone, those without safe access to medical cannabis absolutely deserve the right to add this to their medicine cabinet if they so choose.

Article republished – Source : riseearth.com

Science & Technology

The European Space Agency has released a game about the settlement of Mars

The European Space Agency has released a game about the settlement of Mars 102

The European Space Agency, together with the British company Auroch Digital, released the game Mars Horizon. This is a simulator of the colonization of Mars.

In Mars Horizon, players will have to manage scientific activities, processes in the colony and, of course, finances. You will need to complete missions to make money before sending your astronauts to Mars. The agency directors, who will play the role of the players, will have to fight other large space agencies that pursue the same goals – sending colonists to Mars.

During missions, players are faced with intense turn-based gameplay and each step determines their success or failure. Each individual decision is critical – will you waste time repairing a faulty antenna? How about saving energy in the event of a fuel leak? Maybe if you decide to delay the dispatch of the mission by three months, it will prevent a disaster?

Auroch Digital has created Mars Horizon in collaboration with ESA. The developers consulted with the agency’s staff, including members of the ExoMars mission. ESA provided technical assistance to game developers, provided gameplay advice and tested the game. The developers were given the opportunity to try to manage space projects at the agency’s facilities themselves.

Today you can install the game on PC, Xbox One, PlayStation4 and Nintendo Switch. In the future, the developers want to create special educational versions of the game and put them in schools to show how such large international projects as the colonization of Mars are actually carried out.

Continue Reading

Science & Technology

What’s in store for us in the next decade?

What's in store for us in the next decade? 103

About 70 thousand years ago, Homo Sapiens was an insignificant animal living somewhere on the African continent. But in the millennia that followed, the Sapiens became the rulers of the planet: we subdued the environment, increased food production, built cities and connected them with trade networks. 

But our achievements, no matter how beautiful they look from the outside, have a downside, because our civilization has endangered more than one million species of animals and plants, and the rapid climate change (also the work of man) brings catastrophic consequences every year. But if other, now non-existing civilizations dominated the planet before us, does this mean that we are rapidly approaching sunset? Nobody knows the exact answers to these questions, but let’s try to figure it out.

Great civilizations of the past

Humans have been around for several hundred thousand years, but until the last 7,000 years, we roamed the earth in small groups, hunting, gathering edible plants and fearing threats from other people, animals and weather. Everything changed after the development of tools, weapons and fire, and the first major step towards civilization was the domestication of animals for food, clothing, transportation and communication.

As William R. Nester writes in his work entitled “The Rise and Fall of Civilizations” , plant domestication followed, with small groups settling in river valleys, planting and harvesting. Over the centuries, some of these settlements have developed into complex civilizations that include most or all of the following components:

  • cattle breeding and agriculture; complex, hierarchical political, social, economic, military, and religious institutions, each with a division of labor;
  • the use of metals, wheels and writing; clearly defined territories;
  • trade with other people.

The first “civilization” is believed to have originated in Mesopotamia around 5000 BC. BC, and over the next 6,500 years or so, great civilizations grew and appeared elsewhere, expanded their rule, and then perished for a variety of interconnected political, technological, economic, military, and environmental causes.

What's in store for us in the next decade? 104
Roman civilization originated around the sixth century BC. 
At the height of its power, the Roman Empire ruled over a vast tract of land, and all modern Mediterranean countries were part of ancient Rome.

Roman civilization originated around the sixth century BC. At the height of its power, the Roman Empire ruled over a vast tract of land, and all modern Mediterranean countries were part of ancient Rome.

Recently, scientists have finally solved the mystery of the death of the Mayan civilization – one of the brightest civilizations in the history of mankind, the dawn of which came approximately in the III-IX centuries. As the results of several scientific studies have shown, among the reasons for the death of the Maya, researchers single out several factors at once – droughts, wars, food shortages, etc.

Where is our civilization heading?

According to the data obtained using the ESCIMO computer model, we have just passed the “point of no return” – the moment when humanity could prevent the most severe consequences of rapid climate change. In a paper published in the journal Nature Scientific Reports, the researchers write the following:

“Even if all emissions of harmful substances into the atmosphere are reduced to zero right now, this will not stop the rise in global temperatures.”

And yet, despite this disturbing news, let’s hope that we will meet 2030 and all the decades to come, caring for the environment and looking to the future with optimism. We do not want it, the passage of time is inexorable, and with it the changes in all areas of everyday life. Thus, many researchers regard the near future as a time even more technological than ours.

What will our world be like in 10 years?

Fighting fake news

As stated in an article published on the Science Focus portal, technology can lead us to a world where we will not be sure what is real and what is not. At the same time, thanks to technology, we can distinguish fact from fiction, which is especially relevant in the era of fake news and Deepfake.

For example, some AI startups use machine learning algorithms to identify fakes and errors on the Internet. 

“Fake news and social media have eroded trust in traditional media that have failed to adapt to the new reality. Solving the problem of fake news requires rebuilding the news ecosystem and educating people to think critically and to be more responsible on social media,” Michael Bronstein said, co-founder of AI startup Fabula, a professor of computing at Imperial College London. Well, let’s hope this fight against fake news will be successful.

What's in store for us in the next decade? 105
Most likely, by 2030, technology will help us lead a better life, morally and physically healthy. Jobs are also expected to undergo a number of major changes.

Genetic revolution

Today, many researchers have high hopes for the genome-editing CRISPR method, which can treat hereditary diseases or significantly reduce the risk of developing Alzheimer’s disease. There is even talk of the possibility of reversing the biological aging process. 

But how far can we go in this war on disease? After all, most ailments are caused not by one gene, but by a combination of several genes and environmental factors. Some genes that predispose us to one disease simultaneously protect us from another.

The researchers point out that one of the main challenges today is the costly availability of CRISPR. Moreover, editing the human genome also raises ethical dilemmas – for example, a widely publicized act of a Chinese scientist who used CRISPR-Cas9 technology on unborn babies, for which he is now serving time in prison.

What's in store for us in the next decade? 106
Perhaps over the next 10 years, we will be able to address a number of difficult ethical issues.

However, many scientists hope that in the future, doctors will be allowed to use this technique for the benefit of people, but the “finer details” have yet to be determined. It appears that different cultures will approach ethical issues differently. So in this regard, the future is complex and difficult to predict.

Space revolution

The last time a human foot set foot on the lunar surface was in 1972. Then few could predict that people would not return to Earth’s satellite for another 50 years. As for the latest plans of the world space agencies (both private and public), the plans for the next decade include not only the launch of robotic vehicles, such as the Europa Clipper (scheduled to start in 2021), the James Webb Space Telescope, but also a return to the Moon and human flight to Mars.

In general, speaking about space exploration, we would like to believe that studies of the solar system and the observed Universe in the next 10 years will bring long-awaited news and answers to questions that excite the imagination. 

Technologies of the future from 2020 to 2030

More than 800 experts, economists, businessmen and executives surveyed by the World Economic Forum (WEF) predict the following technologies will be trending. They will make a technological revolution in our world (watch the video below about technologies of the future).

1. AI 2 IoT
3. Blockchain
4. 3D printing
5. Mobile technologies
6. Autonomous cars (transport)
7. Mobile Internet
8 Robotics
9. VR / AR
10. Wireless Power
11. Quantum computing
12. 5G/6G
13. Voice Assistant
14. Cybersecurity
15. Cloud (cloud computing)

Who knows, maybe in 2030 humanity will know for sure that it is not alone in the vastness of the infinite universe. What do you think the world will be like in the near future? 

Continue Reading

Science & Technology

Cancer vaccine shown to be safe and effective has entered human trials

Cancer vaccine shown to be safe and effective has entered human trials 107
University of Montreal

A person, like any living creature, can be vaccinated against cancer, although this disease is fundamentally different from viral infections against which vaccines are traditionally used. 

This has been proven by scientists at Ohio University, who developed a methodology for the use of immune checkpoint inhibitors. Animal studies have shown 90% effectiveness of this therapy and complete safety for the body.

Cancer tumors are extremely insidious and have a defense mechanism against the body’s immune system in the form of the signaling protein PD-1. It is present on both healthy and cancerous cells, and is responsible for the friend-or-foe recognition procedure when immune B and T cells approach them. As long as PD-1 proteins in cancer cells and PD-L1 proteins in lymphocytes are working normally, the immune system simply ignores the infection, not seeing it as a target to attack.

The idea of ​​Dr. Pravin Kaumay, the developer of the inhibitors, is to interfere with the identification procedure. For this purpose, special monoclonal antibodies have been developed, which are injected into the body, seek out PD-1 proteins and settle on them, preventing proper contact with PD-L1 proteins. Lymphocytes cannot recognize these cells and automatically start the procedure for destroying them – the immune system itself begins to eradicate cancerous tumors in the body.

More importantly, blocking the signaling system destroys the usual comfortable environment for cancer cells, they are constantly threatened, cannot grow and spread throughout the body. 

This is the beneficial effect of vaccination with inhibitors – this therapy is called PD1-Vaxx. The technology has been thoroughly tested, it uses second-generation inhibitors, which are much more effective. The first human patients have already been recruited in the US and Australia to test PD1-Vaxx.

Continue Reading
Advertisement

DO NOT MISS

Trending