Connect with us

Metaphysics & Psychology

Gabapentinoids linked to overdoses and suicide

Story at-a-glance –

  • Gabapentin and pregabalin are used for the treatment of epilepsy and neuropathic pain disorders. Pregabalin, such as Lyrica, is also prescribed for anxiety in Europe and fibromyalgia in the U.S.
  • Recent research links gabapentinoids with a 26% increased risk for suicidal behavior and death from suicide; 24% increased risk for unintentional overdose; 22% increased risk for head or body injury due to an accident; 13% increased risk for traffic violations or accidents and 4% increased risk for violent crime offenses
  • Of the two gabapentinoids, pregabalin — which is the newer of the two — was clearly the worst, accounting for most of these adverse effects, while gabapentin — an older drug — showed “no statistically significant hazards”
  • Research published in 2017 demonstrated that concomitant use of gabapentin and opioids raised the risk of death by 60% over and beyond the risk associated with either drug by itself
  • The suicide rate in the U.S. is now at a 20-year high, having risen 30% between 2000 and 2016 across all age groups. Among Native Americans and Alaska Natives the suicide rate between 1999 and 2017 rose 139% among women and 71% among men

Suicide rates are at an all-time high since World War II, and there are several different reasons for this. One of the factors that is often ignored is the influence many medications have on your mental stability. Antidepressants are perhaps the most well-known in this regard, but violent behavior and suicide are side effects of other medications as well.

Most recently, Swedish researchers have linked gabapentinoids — a nonopioid type of analgesic — to “suicidal behavior, unintentional overdoses, injuries, road traffic accidents and violent crime.”1

Two primary gabapentinoids are gabapentin and pregabalin, which are used for the treatment of epilepsy and neuropathic pain disorders. Pregabalin, such as Lyrica2 (which is increasingly associated with addiction and abuse3), is also prescribed for anxiety in Europe and fibromyalgia in the U.S. Globally, this class of drugs was among the 15 best-selling medications of 2016.4

Gabapentinoids are structural analogs of γ-amino butyric acid (GABA) that selectively block voltage-dependent calcium channels.5 Common side effects include dizziness, fatigue, visual disturbances and mental difficulties.6 However, these drugs have also been linked to a significantly increased risk of suicidal behavior.

Gabapentinoids linked to serious hazards, including suicide

The study,7,8 published online in April 2019 in the journal BMJ, examined data on 191,973 Swedish residents who filled gabapentinoid prescriptions in the years between 2006 and 2013.

In that time, 5.2% of them either received treatment for suicidal inclinations or died from suicide; 8.9% unintentionally overdosed, 6.3% were involved in a traffic accident or traffic-related offense; 36.7% were treated for a head or body injury due to an accident, and 4.1% were arrested for a violent crime. The researchers concluded gabapentinoids treatment was associated with:

  • A 26% increased risk for suicidal behavior and death from suicide
  • 24% increased risk for unintentional overdose
  • 22% increased risk for head or body injury due to an accident
  • 13% increased risk for traffic violations or accidents
  • 4% increased risk for violent crime offenses

Of the two gabapentinoids, pregabalin — which is the newer of the two9 — was clearly the worst, accounting for most of these adverse effects, while gabapentin — an older drug — showed “no statistically significant hazards.”

Stratified by age, the risks associated with these drugs were the highest among those aged 15 through 24, and the risks were dose-dependent, so the higher the dose, the greater the risk. According to the authors:10

“This study suggests that gabapentinoids are associated with an increased risk of suicidal behavior, unintentional overdoses, head/body injuries, and road traffic incidents and offences. Pregabalin was associated with higher hazards of these outcomes than gabapentin.”

As is often the case, the risks associated with these drugs have only become apparent as their usage has increased. Dr. Derek K. Tracy of Queen Mary’s Hospital told Reuters that:11

“While it’s not clear why prescribing of gabapentinoids has grown so rapidly … anecdotally it appears that many doctors regarded them as relatively effective and with a low side effect profile.

As we accumulated more information over time, it has become clear that this is not the case, and most recently there has been a countering drive to try reduce their usage as their harm profile came more to the fore.

It is also becoming clearer with time that some people are becoming dependent (“addicted”) to gabapentinoids, though we still lack good information on exactly how common that is, or which groups of people might be more vulnerable to this.”

Concomitant opioid use magnifies risks

Opioids by themselves are associated with a high risk of death through unintentional overdosing, but when combined with other drugs, that risk is significantly magnified.

According to the featured BMJ study,12 research13 published in 2017 demonstrated that concomitant use of gabapentin and opioids raised the risk of death by 60% over and beyond the risk associated with either drug by itself.

Concomitant use of opioids and benzodiazepines or “benzos” — such as Valium, Ativan, Klonopin and Xanax — which are widely prescribed for anxiety and insomnia, also raises your risk of death by a significant margin.

Research14,15 published in the journal JAMA in 2018 found that, during the first 90 days of concurrent use, your risk of a deadly overdose rises fivefold, compared to taking an opioid alone. Between days 91 and 180, the risk remains nearly doubled, after which the risk tapers off, becoming roughly equal to taking an opioid alone.

The study also found that the greater number of clinicians were involved in a patient’s care, the greater the risk of overdose — a finding that highlights the lack of communication between doctors prescribing medication to the same patient, and the clear danger thereof.

Suicide is at a 20-year high

The influence of medication on suicide risk is an important consideration, as suicide rates have dramatically risen over the years. According to the latest statistics16,17 published in the June 2019 issue of JAMA, the suicide rate in the U.S. is now at a 20-year high, having risen 30% between 2000 and 2016 across all age groups.

A couple of groups have seen particularly sharp rises, namely Native Americans and Alaska Natives — among whom the suicide rate between 1999 and 2017 rose 139% among women and 71% among men18 — and teenagers, boys in particular.

Between 2014 and 2017, the teen suicide rate rose 10% per year. Here too, there’s a clear discrepancy between genders, with the annual suicide rate among teen boys, aged 15 through 19, rising 14% between 2015 and 2017, while the annual suicide rate among girls rose 8% between 2000 and 2017.

Lead investigator Oren Miron, a research associate at Harvard Medical School in Boston, told Medicinenet.com,19 “It really is an unprecedented surge. You can go back decades and you won’t find such a sharp increase.” Miron blames the rise on two primary sources: opioid abuse and social media.

“It’s much easier to bully. The apps are getting smarter and smarter at providing anonymity and hiding activity from grown-ups,” he told Medicinenet.com, adding “Parents and teachers need to be aware that the rates have reached their highest recorded level, and they need to be on the lookout for both boys and girls.”

Common contributors to teen suicide

Clinical psychologist and suicide prevention specialist Pamela Cantor, who was not involved in any of the studies mentioned, told Medicinenet.com that “kids are ‘intensely programmed’ to achieve and have too little time to just enjoy their youth.” Other influences identified by Cantor, which can raise a child’s risk of suicide, include:

  • Family instability
  • Social pressure
  • “Parents who try to smooth the way so that when their children hit a snag they do not know how to cope”
  • Exposure to violence, including school shootings and “socially sanctioned expressions of hatred”
  • Easy availability of drugs, alcohol and guns

Suicide among native populations

Among Native Americans, the shocking rise in suicides are thought to be related to20 high rates of poverty,21 lower educational achievements, and high rates of alcoholism. Among women, the extraordinary rise in suicide has also been traced back to unusually high rates of violence.

According to the Indian Law Resource Center, “More than 4 in 5 American Indian and Alaska Native women have experienced violence, and more than 1 in 2 have experienced sexual violence.”22

Alaska Native women have the highest domestic battery rate of any group in the U.S. — 10 times higher than the rest of the U.S. The murder rate of indigenous women is also more than 10 times the national average.23 Race discrimination worsens the tragedy, as a majority of these women never get any kind of justice. As reported by the Indian Law Resource Center:

“For more than 35 years, United States law has stripped Indian nations of all criminal authority over non-Indians. As a result, until recent changes in the law, Indian nations were unable to prosecute non-Indians, who reportedly commit the vast majority (96%) of sexual violence against Native women.

The Census Bureau reports that non-Indians now comprise 76% of the population on tribal lands and 68% of the population in Alaska Native villages. Many Native women have married non-Indians.

However, it is unacceptable that a non-Indian who chooses to marry a Native woman, live on her reservation, and commit acts of domestic violence against her, cannot be criminally prosecuted by an Indian nation and more often than not will never be prosecuted by any government.”

Children whose parents use opioids have greater suicide risk

In related news, recent research24 shows children and teens whose parents use opioids have more than double the suicide rate — 0.37% compared to 0.14% — of those whose parents do not use opioids. In a press release, senior author Robert Gibbons, Ph.D., professor of biostatistics and director of the Center for Health Statistics at the University of Chicago, stated:25

“We theorized such a link was plausible because parental substance abuse is a known risk factor for suicide attempts by their children. In addition, depression and suicide attempts by parents — which are known to be related to suicidal behavior in their offspring — are more common among adults who abuse opioids.”

Co-author Dr. David A. Brent, psychiatrist and chair of suicide studies at the University of Pittsburgh commented on the results:26

“These findings demonstrate that opioid use by a parent or parents doubles the risk for suicidal behavior by their children. The epidemics of adult opiate abuse and child suicidal behavior appear to be linked, and the disturbing upward trends in mortality due to opiates and due to child suicide may have common roots.”

Red Flags — Is someone you know suicidal?

If someone close to you has recently endured a hardship, or you have noticed a change in their behavior, how can you tell when ordinary stress or sadness has progressed to a potentially suicidal level? Besides straightforward or “sideways” comments about not wanting to live any longer, some of the red flags that a person has a high risk for self-harm include:27

Acquiring a weapon

Hoarding medication

No plan for the future

Putting affairs in order

Making or changing a will, or writing about feeling hopeless or suicidal

Giving away personal belongings for no apparent reason

Mending grievances

Checking on insurance policies

Social withdrawal

Sudden mood swings

Frequent and/or increased use of drugs or alcohol

Engaging in risky behaviors

If you think someone is suicidal, do not leave him or her alone. A person who appears suicidal needs immediate professional help. Help the person to seek immediate assistance from their doctor or the nearest hospital emergency room, or call 911. Eliminate access to firearms or other potential suicide aids, including unsupervised access to medications.

If you are feeling desperate or have any thoughts of suicide, call the National Suicide Prevention Lifeline, a toll-free number, at 1-800-273-TALK (8255), or call 911, or simply go to your nearest hospital emergency department.

Source link

Comments

Metaphysics & Psychology

Man is able to induce controlled hallucinations without psychotropic substances

The human brain is so cunningly designed that accidental damage or malfunctions in the neural network can generate large-scale effects that do not harm a person, but, on the contrary, deliver a lot of new sensations. 

We are talking about hallucinations, influences on the sensory system, which stem from the inside of the brain itself. Modern technologies make it possible to purposefully launch such reactions without harm to humans.

The technique of guided hallucinations is based on the Ganzfeld effect, which states that when the brain receives a powerful stimulating signal in only one area, it automatically begins to “think out” signals in other areas. 

For example, if you peer into the darkness and listen to white noise, the brain draws an imaginary picture, although the eyes do not receive a single photon of light. And if you run noise on the screen in absolute silence, the brain will complement them with sound hallucinations.

Hallucinations

One interesting experiment with guided hallucinations was conducted by TV host and inventor Derek Müller, who locked himself in an anechoic and completely darkened chamber for 45 minutes to conduct a sensory deprivation experiment. 

His brain, which at once lost 90% of the signals from the outside world, remained fully functional, and Derek did not go crazy. Moreover, in the absence of external stimuli, he began to feel the subtlest vibrations of his heart and the flow of blood through the veins. 

It was not a hallucination, it was just that the brain switched to processing the signals that remained at its disposal, amplifying them and presenting them in the form of sensations understandable to the mind.

Continue Reading

Metaphysics & Psychology

Angels showed the End of the World to a child from Indonesia?

In early October, on many eschatological and conspiracy sites (The End Times Forecaster , 444prophecynews.com), a video was posted by a girl named Jacqueline, who lives in South Africa. The video tells that on September 16, in some altered state of consciousness, similar to a lucid dream, Jacqueline was given a warning: on October 10, 2020, there will be some kind of nightmarish geological catastrophe – either a volcanic eruption, or an earthquake. 

Jacqueline does not specify where the catastrophe will occur, but immediately after the volcanic eruption, she saw President Trump in Washington and the destruction of the Washington Monument with fiery stones falling from the sky. The full text of Jacqueline’s video was posted on the forum and can be viewed at the link, but her revelation itself is not very informative. It is only clear that on October 10 something may bang, and very strongly. Another thing is much more interesting. 

Since Jacqueline was shown truly creepy things, she, like anyone in her place, doubted that all this was true. However, she noticed that in her dream, before the horror broadcast began, she was shown a calendar on which she read the KIMIKO inscription.

“Kimiko” is a popular Japanese female name that literally means “wonderful unusual child”, so Jacqueline decided: if she got it right, then she needed to look for a girl from somewhere in Japan who would kind of hint at her deciphering what was shown in her dream. 

Kimiko was never found, but another girl named Catherine was found. She lives in Indonesia, is in 4th grade and is 9 years old. Jacqueline had her dream on September 16, and on September 18 some angels took this Catherine to heaven in a dream and showed her what would be on Earth in the very near future. 

According to Catherine, everything will begin on October 10, 2020, when some kind of catastrophe occurs – a catastrophe, most likely of a geological nature. Buildings will collapse and coastal cities will suffer from terrible tsunamis. At the same time, a terrible rain will pour, which in some regions will flood buildings up to the fourth floor. Thunder will thunder in the sky, which is 10 or even 20 times stronger than ordinary thunder, and after the thunder, hail will fall the size of a car windshield. But besides the hail, all the planes located there fall from the sky. 

However, the End of the World will not happen as life goes on and Trump wins the US election. After that, Israel will begin to restore the Temple, but they will not have time, since a war will start around. At this moment, the Earth will face unprecedented catastrophes.

A huge new planet will appear in the sky and the atmosphere will take on a reddish tint. It will get hotter. H achnut erupting volcanoes, and terrifying winds will become commonplace. And further, in the region of the Bermuda Triangle, a hole is formed in the lithosphere, and armada of some strange flying machines will appear from there. On TV they will say that these are good aliens. 

In parallel , a total vaccination will take place on Earth, after which people who have received the vaccine will be endowed with some unthinkable ability to communicate with their gadgets – phones will show them everything at the click of a finger and connect to subscribers with the power of thought. But happiness will not last long, because then the skin of the vaccinated will begin to turn green and many will be covered with ulcers. Further, these people mutate into a kind of zombie who will engage in cannibalism and those who have not taken the vaccine will become their preferred food. And for those who will not be eaten by mutants, aliens will chase in their flying cars, kidnap, throw bombs at them and burn them with rays. 

Finally, to top it all off, mutations will affect flora and fauna. So, insects will become gigantic, and algae will begin to crawl ashore and whoever gets into their nets will be devoured. Mutations will affect birds, jellyfish, and the rest of the fauna. Dinosaurs and real fire-breathing dragons will appear, which will fly everywhere and pour fire on everything. 

In general, the girl tells something that is impossible to believe – no reality can stand that. However, the probability that reality is real, according to estimates of the theory of probability, is no more than 50%. That is, we live in the Matrix with a probability of 1/2, although nothing can be proved / disproved somehow. But if we take into account various strange quantum effects and other miracles, then the probability of the Matrix is ​​already seventy percent and 30% remain for a flat / round Earth, for the rest of “natural science”. Therefore, maybe we are now on the eve of the reboot of the Matrix, during which we will begin to load characters from other entertaining games. 

It is possible, of course, that all these stories were invented by her mother, but similar stories are told by other children, and even adults, who were thrown either somewhere into the astral plane, or into the next world, or generally into the deepest warp. Different, unrelated people cannot tell the same tale. Therefore, most likely this is not a fairy tale and there is something in all this. But what – here we do not know, so we just have to wait and see. 

Continue Reading

Metaphysics & Psychology

Clinical death helped the inveterate egoist to change his attitude towards life. He is grateful for this experience

William F. did not live the most righteous life. His selfish, authoritarian behavior caused a lot of suffering to the people around him, especially his wife. And it is not known how his marriage would have ended if one day William had not had an accident.

On that fateful day, November 6, 2019, a man was riding a motorcycle and crashed into a truck as it changed lanes. William tried unsuccessfully to get out from under the heavy truck, as his helmet got stuck under the front axle of the car.

A policeman was the first to come to help, then an ambulance arrived. The motorcyclist was evacuated by helicopter to the hospital. The man in the helicopter told William not to sleep, but he collapsed into unconsciousness.

What William saw in oblivion made a strong impression on him and changed his future life.

xusenru / pixabay.com / Pixabay License

William’s near-death experiences

The next thing I remember happened on a large field. There was a fence about 100 meters away from me. There was a black hole in the fence on the other side of the gate.

I was drawn to the gate. The closer I got, the more love and warmth I felt, the more selfishness and bad feelings went away.

When the gate was about five steps away, and I was about to open it, someone’s hand stopped me, grabbing my forearm. Looking at this man, I noticed a few more.

– You need to stop. I watched you for a long time, son, you made a lot of mistakes. Do you know where you are? The man asked.
“I’m not sure,” I said, looking around.
“You are dead,” he said.

I panicked.

“You’re scared,” he remarked.
– No.
“Then [during your life] you were always afraid of it for no reason,” he said softly. I nodded in agreement, and our dialogue continued.
– Do you feel that everything is under your control?
“I don’t know… no.
– You have never controlled anything in your life. It’s an illusion …
– Yes, you’re right, – I nodded again.
– You are given a choice that many do not have. God gives you a choice: come back and correct your mistakes, or you can go through the gate. If you enter this gate, all the regrets of life will torment your soul until you are given another chance. It will feel like eternity.

I still have regrets about my past life, ”he added after a pause. – If you come back and do not start working on yourself to become better, if you do not find happiness in the righteous way, you will always remember and crave the feeling that you are experiencing in this place now, but you will not get here again.
When you return, recover, heart and mind will be restored. You are given something great … But you understand that God already knows your choice.

Then he looked at me and asked:

– What are you going to do?
“I’ll be back,” I replied.

At that moment, the feelings that gripped me were gone, and I let go of the gate.

“See you again very soon,” he said at last.

Then I woke up and saw my mother. I told her that I was back for good and that I would not go anywhere. She had a tired face.

“You’ve been in a lot of pain,” she said.

I said that everything would be all right with me, and told that I saw Him. She clarified who exactly. I replied that I did not know for sure, but they gave me a second chance. Mom laughed and said that probably my grandfather kicked me in the ass to bring me back here.

William’s life has changed

William underwent several operations, but the doctors said that physically he would not be the same. Among other things, the man had to learn to walk again.

About a month after the accident, thoughts of the pain inflicted on his loved ones and loved ones flooded into William, so he focused on correcting the mistakes of the past and changing his future.

Five months later, William was walking without limping. Now she runs for several kilometers, and the only evidence of an accident is scars.

The biggest proof of the reality of what he saw during clinical death is a complete change in himself, says William.

haomao57 / pixabay.com / Pixabay License

“I saw mistakes, especially in my relationship with my wife, and I understand things that I didn’t understand before. It is strange to think that someone was watching my life from a distance and knew about my actions. If I had not changed, I would have yearned for death. “

“I used to have sociopathic tendencies and no empathy. I have never felt guilt or remorse. Now I am selfless and empathetic, I feel the emotions of others, and it is overwhelming. I know how people feel just by looking at them. This is a kind of intuition.

Remorse and guilt help me re-evaluate the past. I also notice that when I do something instinctively, in the old way, I realize it and I can stop. “

“People believe when I share my experience because they see a big change in me.”

Source: NDERF

Continue Reading
Advertisement

DO NOT MISS

Trending