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DNA would not be unique: there may be millions of possible genetic molecules

A team of scientists used a computer program to discover more than 1 million molecules that could store genetic information, just like DNA.

DNA and its cousin RNA store genetic information and allow life as we know it, but what if millions of lesser known chemicals could do exactly the same?

A new study suggests that more than 1 million similar chemicals could encode biological information in the same way as DNA does. The new study could point the way to new goals for pharmaceutical drugs, explain how life on Earth evolved and even help us find ways to live beyond our planet, according to the authors.

Jay Goodwin, chemist at Emory University and co-author of the study, said in a release:

It is really exciting to consider the potential of alternative genetic systems … that could possibly have arisen and evolved in different environments, perhaps even on other planets or moons within our solar system. ”

DNA and RNA, the two known types of nucleic acids contain chemical bits called nucleotides, which bind in a particular order and transmit different data, depending on their sequence, similar to individual letters within a written sentence. Some natural and artificial molecules mimic the basic structure of DNA, but so far, no one had tried to count how many of these similarities could exist, the authors wrote.

DNA is only one among millions of possible genetic molecules
Credit: lisichik / Pixabay

Jim Cleaves, chemist at Tokyo Institute of Technology said in a statement:

There are two types of nucleic acids in biology. We wanted to know if there is one more to find or even a million more. The answer is that there seems to be many, many more than expected. ”

Simulating DNA-like molecules

The authors designed a computer program to generate chemical formulas for molecules similar to nucleic acids. In DNA, nucleotides are joined in different pairs and joined in a line, so scientists made sure that their generated molecules could be formed in the same way. In the end, his program gathered more than 1,160,000 different molecules that met these basic criteria.

Markus meringer, chemist at German Aerospace Center in Cologne, said in a statement:

“We were surprised by the result of this calculation. It would be very difficult to estimate a priori that there are more than one million scaffolds similar to nucleic acids. Now we know, and we can start analyzing some of these in the laboratory. ”

Credit: PublicDomainPictures / Pixabay

The multitude of similarities can clarify the story of how life arose on Earth, before DNA and RNA dominated the world of biology. Theoretically, evolution may have performed “tests” with some of these other molecules before establishing nucleic acids as the best carriers of genetic data, the authors suggested.

The similar ones can also boost future medical advances, they added. According to the statement, drugs that resemble nucleotides are already used to undermine dangerous viruses and malignant cancer cells in the human body. With a library of structurally similar molecules at hand, drug developers could adopt similar DNA as an important weapon in the fight against disease.

Pieter Burger, biochemist of the Emory University said in a statement:

It is absolutely fascinating to think that through the use of modern computational techniques we could find new medicines by looking for alternative molecules to DNA and RNA that can store hereditary information. ”

The scientific study has been published in Journal of Chemical Information and Modeling.

Source: Live science

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Science & Technology

Japan has developed an inflatable scooter that weighs practically nothing

The University of Tokyo engineers have developed the Poimo inflatable electric scooter, which is created individually for each owner. It is enough to send your photo to the manufacturers – and a personal optimized model will be assembled for you.

The scooter is designed with a special program for the body size of a particular user and his specific fit. Moreover, each owner is free to make any changes to this model. If he makes any changes to the drawing, the program will automatically redesign the electric bike to maintain its strength, stability and controllability. When the model is finished and approved, it is handed over to the manufacturer.

Scooter Poimo

The scooter consists of seven separate inflatable sections that are constructed from durable fabric and sewn with straight stitch. It remains to add electronic components – in particular, a brushless motor and a lithium-ion battery. 

The finished electric scooter weighs about 9 kg and can travel at speeds up to 6 km / h (that is, slightly faster than a pedestrian). It can work for an hour on one charge.

This is how the current version of Poimo looks like in action:

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Excerpts from Elon Musk’s speech at the Martian Society convention

Elon Musk’s comments with questions relayed from the Mars Society Membership by Dr. Robert Zubrin, James L. Burk, and Carie Fay. Following Elon’s 30 min time, Dr. Zubrin took additional questions. This special event was part of the 2020 Mars Society Virtual Convention from October 14-18, 2020.

About Starship Test Schedule:

– entering orbit – with a probability of 80% -90% will take place in 2021

– the probability of the return of the ship and the 1st stage in this flight is 50%

– test of refueling in orbit – 2022

– Starship lunar version – 2022 or 2023

– Starship flight to Mars – around 2024

The goal of the Starship is to build a self-sufficient settlement on Mars as quickly as possible. Musk does not rule out the possibility that this will not be achieved during his lifetime. According to his rough estimates, to create a self-sufficient city, it will be necessary to deliver 1 million tons of cargo, which corresponds to 4-5 million tons in a low Earth orbit. Modern single-use launch vehicles are capable of removing less than 1% of this value.

“Disposable launch vehicles are completely stupid. They are a waste of time. I think people need to stop wasting time on this. If you try to sell a disposable plane, you will be thrown out of the office. If you try to sell a disposable car, you will also be thrown out of the office. “

A series of questions and answers followed:

What is the best landing site on Mars?

– I’m not sure about that. But I can name the criteria. The first of these is latitude: most likely it will be in the northern hemisphere, far enough to the north to have water ice, but to still have enough sunlight.It also needs to be low to get the most benefit from atmospheric braking.

How do you prioritize mission priorities: research, infrastructure construction, and science?

– The first will be the construction of a fuel plant.

A question from a teenager who wants to become an engineer and robot maker with a dream to work at SpaceX: what is the most important education in order to become an engineer?

– There are many varieties of this profession: you can be an aerospace engineer, in the field of electronics, software, or a chemical engineer involved in creating safe production of fuels. I think physics is a good foundation for critical thinking.

Boring Company was originally conceived as a tunnel manufacturing firm on Mars?

– No. It was originally something of a joke. I thought tunnels were a good solution to reduce the traffic problem in cities and improve the quality of life by turning parking lots into green parks. To do this, you need to go to 3d [get away from the “flat” infrastructure – approx. per.]. I think tunnels are good for Mars too. But there you need a lot lighter equipment: you don’t care about mass on Earth, but you will have to take care of it a lot when going to Mars.

At Boring Company, have you learned a lot of technology that might come in handy on Mars?

– I think, yes.

Do you have any tips for young people who love Mars but don’t know how to participate in its settlement?

– I think any strong advocate of the need to conquer Mars matters. People often don’t even think about it. I often talk to people who don’t even know about it. Therefore, I consider it important for humanity and consciousness in general to bring a discussion about this to society. Talking about it with friends and acquaintances – I think this is what we should do. In my estimate, we will spend less than 1% of our efforts on Mars exploration, exactly less than healthcare, perhaps even less than cosmetics – this will be enough to make life multi-planetary. But this requires people to start talking about it 100 times more often. I think this is what really matters. [the entire cosmonautics of the world is $ 424 billion a year, while cosmetics is $ 532 billion, and tobacco production is $ 849 billion – approx. per.]

What’s the coolest part about Starship development?

– I think the coolest detail is the ability to work with a great group of engineers and come up with interesting solutions. I think the best thing is the opportunity to work with smart and creative people who come up with solutions that were not available before. This is a great reward.

What do you focus on when hiring, especially with regard to engineers?

“We’re looking for signs of exceptional ability. Or at the very least, striving to do exceptional things at SpaceX.

Are you planning to make a Mars-Earth communication system like Starlink?

– Yes, I think we will use a laser, probably launched into orbit, to avoid atmospheric diffraction. Thus, it will be a laser beam going from the orbit of the Earth to the orbit of Mars. And also relay satellites in solar orbit, since the laser beam cannot be sent through the Sun [when it is between Mars and Earth – approx. per.].

Can Starship be used for other destinations like Venus and other planets?

– Starship will be able to travel to any target in the solar system that has a solid surface when fuel depots appear. It is not the kind of transport that will take us to other stars, but when we become a multi-planetary species, we will create a demand for innovation in space travel that will ultimately lead us to interstellar travel.

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Cern Scientists Plan an Impressive Experiment – They Will Come Into A Parallel Universe

Cern scientists are once again preparing to impress the entire planet and become the focus of discussions with the new experiment they are planning.

An experiment that, if it brings the fascinating result that scientists have in mind,  will change the way we think about the world , will take place in the next few days at the Large Hadron Collider, the European nuclear center, Geneva CERN Research.

The astonishingly LHC complex, the largest, most energetic elemental accelerator in the world,  will be “fired” for the first time to its highest energy levels, in an effort to detect – or even create – tiny black holes. 

If it succeeds, then, a completely new universe will be revealed – rewriting not only the books of physics, but also the books of philosophy! 

It is possible, however,  that gravity from our universe will “leak” into this parallel universe, as LHC scientists say. 

From the Higgs boson to dark matter and the parallel universe

According to the British Express, the experiment is sure to “trigger” the critics, who are worried about the LHC, many of whom warn that the elementary particle accelerator will mark the end of our universe, creating a of the black hole.

Nevertheless,  Geneva has remained … intact since 2008, when the LHC began its spectacular “work”.

The first scientists at the Large Hadron Collider proved the existence of the Higgs boson – a key building block of the universe – and the LHC appears to be on track to locate “dark matter” – a previously undetectable force now considered that it constitutes the majority of matter in the universe, being, in fact, the reason why the latter is constantly expanding and moving away. 

So next week’s experiment is considered to change the game. 

The truth is out there

Mir Faizal, one of three heads of the three natural groups behind the experiment, said: 

“Like many parallel sheets, which are two-dimensional objects (width and length) can exist in a third dimension (height) , so parallel universes can also exist in higher dimensions. We anticipate that gravity can leak into extra dimensions, and if that happens, then tiny black holes can be produced in the LHC. 

Normally, when people think of the multiverse, they think of the interpretation of quantum mechanics by many worlds, where every possibility is realized. This cannot be tested and so it is a philosophy and not a science. We do not mean this with parallel universes. What we mean is real universes, in extra dimensions. The truth is out there.”

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