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Designing people: GMO generation

Many of us are born with qualities that help us better compete in society: beauty, intelligence, spectacular appearance or physical strength. Due to the success of genetics, it begins to seem that soon we will become available to something that was not previously subject to – to “design” people even before they were born. 

To ask the necessary qualities, if they are not given by nature, predetermining the opportunities so necessary in life. We do this with cars and other inanimate objects, but now that the human genome has been decoded and we are already learning to edit it, it seems that we are getting closer to the emergence of so-called “designer”, “designed” children. Does it seem that way or will it soon become reality?

Lulu and Nana from Pandora’s Box

The birth of the first children with a modified genome at the end of 2019 caused a serious resonance in the scientific community and among the public. He Jiankui, a biologist at the Southern University of Science and Technology, China  (SUSTech)   – On November 19, 2018, on the eve of the second International Summit on Human Genome Editing in Hong Kong, in an interview with the Associated Press,  announced the birth of the first children in history with an edited genome.

The twin girls were born in China. Their names, as well as the names of their parents, were not disclosed: the first “GMO children” on the planet are known as Lulu and Nana. According to the scientist, the girls are healthy, and interference with their genome has made the twins immune to HIV.

The event, which may seem like a new step in the development of mankind, or at least medicine, as already mentioned, did not cause positive emotions among the scientist’s colleagues. On the contrary, he was condemned. Government agencies in China began an investigation, and all experiments with the human genome in the country were temporarily banned.

He Jiankui /  ©  apnews.com/Mark Schiefelbein

The experiment, not appreciated by the public, was as follows. The scientist took sperm and eggs from the future parents, carried out in vitro fertilization with them, he edited the genomes of the resulting embryos using the CRISPR / Cas9 method  . After the embryos were implanted into the lining of the woman’s uterus, the girls’ expectant mother was not infected with HIV – unlike the father, who was a carrier of the virus.

The CCR5 gene , which encodes a membrane protein used by the human immunodeficiency virus to enter cells, was edited  . If it is modified, a person with such an artificial mutation will be resistant to infection with the virus.

Lulu and Nana /  ©  burcualem.com

The mutation that He Jiankui tried to create artificially is called  CCR5 Δ32 : it is also found in nature, but only in a few people, and has long attracted the attention of scientists. Experiments in mice in 2016 showed that  CCR5 Δ32  affects the functioning of the hippocampus, significantly improving memory. Its carriers are not only immune to HIV, but also recover faster after a stroke or traumatic brain injury, have better memory and learning abilities than “ordinary” people.

However, so far no scientist can guarantee that  CCR5 Δ32  does not carry any unknown risks and that such manipulations with the CCR5 gene   will not cause negative consequences for the carrier of the mutation. Now the only negative consequence of such a mutation is known: the organism of its owners is more susceptible to West Nile fever, but this disease is quite rare.

Meanwhile, the university where the Chinese scientist worked disowned its employee. The alma mater stated that they did not know about He Jiankui’s experiments, which they called a gross violation of ethical principles and scientific practice, and he was engaged in them outside the walls of the institution.

It should be noted that the project itself did not receive independent confirmation and did not pass peer review, and its results were not published in scientific publications. All we have is just a scientist’s statements.

He Jiankui’s work violated the international moratorium on such experiments. The ban is established at the legislative level in almost all countries. Colleagues of the geneticist agree that the use of CRISPR / Cas9 genomic editing  technology  in humans carries enormous risks.

But the key point of criticism is that the work of the Chinese geneticist has nothing innovative: no one has undertaken such experiments before due to fear of unpredictable consequences, because we do not know what problems modified genes can create for their carriers and descendants.

As the British geneticist Maryam Khosravi said on her Twitter account: “If we can do something, it does not mean that we have to do it.”

By the way, in October 2018, even before the shocking statement of the Chinese scientist, Russian geneticists from the Kulakov National Medical Research Center of Obstetrics, Gynecology and Perinatology also announced the successful change of the CCR5  gene  using the CRISPR / Cas9 genomic editor   and obtaining embryos that are not subject to the effects of HIV. Naturally, they were destroyed, so that it did not come to the birth of children.

40 years before

Fast forward four decades. In July 1978, Louise Brown was born in the UK – the first child born as a result of in vitro fertilization. Then her birth caused a lot of noise and indignation, and went to the parents of the “test-tube baby”, and the scientists, who were nicknamed “doctors of Frankenstein.”

Louise Brown. In childhood and now /  ©  dailymail.co.uk

But if that success frightened some, it gave others hope. So, today on the planet there are more than eight million people who owe their birth to the IVF technique, and many of the prejudices that were popular then have been dispelled.

True, there was one more concern: since the IVF method assumes that a “ready” human embryo is placed in the uterus, it may be genetically modified before implantation. As we can see, after a few decades, this is exactly what happened.

IVF procedure /  ©  freepik.com

So can a parallel be drawn between the two events – the birth of Louise Brown and the Chinese twins Lula and Nana? Is it worth arguing that Pandora’s box is open and very soon it will be possible to “order” a child created according to a project, that is, a designer one. And most importantly – will the attitude of society towards such children change, as it has practically changed towards children “from a test tube” today?

Embryo selection or genetic modification?

However, it’s not just genome editing that brings us closer to a future where children will have pre-planned qualities. Lulu and Nana owe their birth not only to CRISPR / Cas9 gene editing  technologies  and IVF, but also to preimplantation genetic diagnosis of embryos (PGD). During his experiment, He Jiankui used PGD of edited embryos to detect chimerism and off-target errors.

And if editing human embryos is prohibited, then preimplantation genetic diagnostics, which consists in sequencing the genome of embryos for some hereditary genetic diseases, and the subsequent selection of healthy embryos, is not. PGD ​​is a kind of alternative to prenatal diagnostics, only without the need to terminate pregnancy in case of genetic abnormalities.

Experts point out that the first “legitimate” designer children will be obtained precisely through the selection of embryos, and not as a result of genetic manipulation.

In the process of PGD, embryos obtained using in vitro fertilization are subjected to genetic screening. The procedure involves removing cells from embryos at a very early stage of development and “reading” their genomes. All or part of the DNA is read to determine which variants of genes it carries. Afterwards, the parents-to-be will be able to choose which embryos to implant in the hope of pregnancy.

Preimplantation genetic diagnosis (PGD) /  © vmede.org

Preimplantation genetic diagnosis is already being used by couples who believe they carry genes for certain inherited diseases to identify embryos that lack those genes. In the United States, such testing is used in about 5% of IVF cases. It is usually performed on three to five day old embryos. Such tests can detect genes that carry about 250 diseases, including thalassemia, early Alzheimer’s disease and cystic fibrosis.

However, today PGD is not very attractive as a technology for designing children. The procedure for obtaining eggs is unpleasant, carries risks and does not provide the required number of cells for selection. But everything will change as soon as it becomes possible to obtain more eggs for fertilization (for example, from skin cells), and at the same time, the speed and cost of genome sequencing will increase.

Bioethicist Henry Greeley of Stanford University in California states, “Almost everything you can do with gene editing, you can do with embryo selection.”

Is DNA Destiny?

According to experts, in the coming decades in developed countries, progress in technologies for reading the genetic code recorded in our chromosomes will give an increasing number of people the opportunity to sequence their genes. But using genetic data to predict what kind of person an embryo will become is harder than it sounds.

Research into the genetic basis of human health is certainly important. Still, geneticists have done little to dispel simplistic ideas about how genes affect us.

Many people believe that there is a direct and unambiguous connection between their genes and traits. The idea of ​​the existence of genes directly responsible for intelligence, homosexuality, or, for example, musical abilities, is widespread. But even using the example of the aforementioned CCR5 gene  , a change in which affects the brain, we saw that everything is not so simple.

There are many – mostly rare – genetic diseases that can be accurately recognized by a specific gene mutation. As a rule, there really is a direct connection between such a gene breakdown and the disease.

The most common diseases or medical predispositions – diabetes, heart disease, or certain cancers – are associated with several or even many genes and cannot be predicted with any certainty. In addition, they depend on many environmental factors – for example, on a person’s diet.

But when it comes to more complex things like personality and intelligence, we don’t know much here about which genes are involved. However, scientists do not lose their positive attitude. As the number of people whose genomes have been sequenced increases, we will be able to learn more about this area.

Meanwhile, Euan Birney, director of the European Bioinformatics Institute in Cambridge, hinting that decoding the genome will not answer all questions, notes: “We must get away from the idea that your DNA is your destiny.”

Conductor and orchestra

However, this is not all. Not only genes are responsible for our intelligence, character, physique and appearance, but also epigens – specific tags that determine the activity of genes, but do not affect the primary structure of DNA.

If the genome is a set of genes in our body, then the epigenome is a set of tags that determine the activity of genes, a kind of regulatory layer located, as it were, on top of the genome. In response to external factors, he commands which genes should work and which should sleep. The epigenome is the conductor, the genome is the orchestra, in which each musician has his own part.

Such commands do not affect DNA sequences, they simply turn on (express) some genes and turn off (repress) others. Thus, not all genes that are on our chromosomes work. The manifestation of a particular phenotypic trait, the ability to interact with the environment, and even the rate of aging depend on which gene is blocked or unblocked.

The most famous and, as it is believed, the most important epigenetic mechanism is DNA methylation, the addition of CH3 group by DNA enzymes – methyltransferases to cytosine – one of the four nitrogenous bases in DNA.

Epigenome /  ©  celgene.com

When a methyl group is attached to the cytosine of a gene, the gene is turned off. But, surprisingly, in such a “dormant” state, the gene is passed on to the offspring. Such a transfer of characters acquired by living things during life is called epigenetic inheritance, which persists for several generations.

Epigenetics – the science called the little sister of genetics – studies how turning genes on and off affects our phenotypic traits. According to many experts, it is in the development of epigenetics that the future success of the technology for creating designer children lies.

By adding or removing epigenetic “tags”, we can, without affecting the DNA sequence, fight both diseases that have arisen under the influence of unfavorable factors, and expand the “catalog” of the planned child’s design characteristics.

Is the Gattaki scenario and other fears real?

Many fear that from editing the genome – in order to avoid serious genetic diseases – we will move on to improving people, and there it is not far before the emergence of a superman or the ramification of humanity into biological castes, as Yuval Noah Harari predicts.

Bioethicist Ronald Greene of Dartmouth College in New Hampshire believes technological advances can make “human design” more accessible. In the next 40-50 years, he says:

“we will see the use of gene editing and reproductive technologies to improve humans; we can choose the color of eyes and hair for our child, we want improved athletic ability, reading or numeracy skills, and so on.”

However, the emergence of designer children is fraught with not only unpredictable medical consequences, but also deepening social inequality.

As bioethical scientist Henry Greeley points out, a 10% to 20% achievable health improvement through PGD that complements the benefits already generated by wealth could lead to a widening gap in the health status of rich and poor, both in society and between countries.

And now, terrible images of a genetic elite, like the one depicted in the dystopian thriller Gattaca, arise in the imagination: the progress of technology has led to the fact that eugenics has ceased to be considered a violation of moral and ethical norms, and the production of ideal people is put on stream. 

In this world of humanity is divided into two social classes – “fit»  (the valid)  and “worthless»  (in-the valid) . The former, as a rule, are the result of the parents’ visit to the doctor, and the latter are the result of natural fertilization. All doors are open to “good”, and “unfit”, as a rule, are overboard.

Still from the film “Gattaca” (1997, USA)

Let’s return to our reality. We noted that it is not yet possible to predict the consequences of interference with the DNA sequence: genetics does not provide answers to many questions, and epigenetics is actually at an early stage of development. Each experiment with the birth of children with a modified genome is a significant risk that in the long term can turn into a problem for such children, their descendants and, possibly, the entire human species.

But the progress of technology in this area, having saved us, probably from some problems, will add new ones. The emergence of perfect in all respects designer children who, having matured, become members of society, can create a serious problem in the form of deepening social inequality already at the genetic level.

There is another problem: we did not look at the topic under consideration through the eyes of a child. People sometimes tend to overestimate the capabilities of science, and the temptation to replace the need for painstaking care of their child, his upbringing and study with paying bills in a specialized clinic can be great. What if the designer kid, in whom so much money has been invested and who has so many expectations, falls short of those hopes? If, despite the intelligence programmed in the genes and a spectacular appearance, he does not become what they wanted to do? Genes are not destiny yet.

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Underworld

Trump said the US has weapons systems that no one knows about

The United States has weapons systems that no one knows about. American President Donald Trump told this to reporters on Thursday before leaving for Michigan.

The head of state was asked to comment on the allegations from the upcoming book by American journalist Bob Woodward, ‘Rage’. The book is based, among other things, on 18 of Woodward’s exclusive interviews with Trump. According to the journalist, the President of the United States in conversations with him, among other things, stated that the United States has developed a new nuclear weapons system, which neither Russia nor China has analogues of.

“We have excellent weapons. No, I’m not talking about classified [information], I’m talking about what we have created. We create great weapons. Our Armed Forces are stronger than ever. We have spent $ 2.5 trillion on our aircraft over the past 3.5 years. Now we have new missiles <…>. I hope we never have to use it, but our nuclear [weapons] are now at their best in decades,” Trump responded.

“We have some systems that no one knows about. To be honest, it seems to me that it would be better to keep this way. We have some incredible systems,” continued the head of the White House.

The President of the United States also made a statement that the United States possesses the best weapons in the world, the likes of which neither Russia nor China has.

“We have invested 2.5 trillion in the US military. You know, with these false media, I said: “We have systems and missiles <…>. We have systems that you have never even seen before, [Chinese President] Xi [Jinping] has nothing like it, [Russian President Vladimir] Putin has nothing like it. No one has anything like what we have.” And they said, “Is he giving out [secret] military information?” No, I’m saying we have the greatest weapon in the world, ”said the US President, speaking to supporters in Michigan.

“They say, ‘He may be revealing classified information.’ You don’t have to worry about it. These people are sick,” Trump continued.

Excerpts from Woodward’s book on the development of nuclear weapons were published on Wednesday by The Washington Post. As the publication clarifies, Woodward’s sources “later confirmed that the US Armed Forces have a new secret weapons system.” Woodward declined to give details on this. “[Woodward’s] sources were surprised that Trump revealed” the existence of the system, the newspaper said.

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Underworld

We are already in the Loop: The Covid-19 Endless quarantine

From the world’s “top” to the “bottom” media are broadcasted completely inconsistent forecasts regarding the further prospects for the spread of coronavirus infection and a new tightening of anti-epidemic measures.

However, the same uncertainty and inconsistency is evident even at the global level. While epidemiologists, relying on statistical data on the dynamics of “covid” morbidity and mortality in different countries of the world, are predicting a “second wave” of this infection for mankind, officials of the World Health Organization (WHO), in particular – the head of the division of this structure for new diseases and zoonosis, Maria Van Kerkhov, declare that the “first wave” of the coronavirus pandemic did not exist in nature.

It turns out there are good reasons for this: on March 11, 2020, the pandemic was declared “in advance” , due to the almost simultaneous detection of a large number of patients around the world outside the original focus of infection in the Chinese city of Wuhan.

By the way, this happened literally the next day after Chinese President Xi Jinping personally arrived in Wuhan and proclaimed victory over the coronavirus.

Almost six months have passed since that moment. The total number of infected people as of August 31, 2020 amounted to slightly more than 25.5 million people (0.32% of the world’s population), the death toll – slightly more than 852 thousand people (the average world mortality rate is 3.3%). As you wish, but this data does not “pull” into a real pandemic. From the word “absolutely”. Moreover, about 170 thousand people die every day in the world, and since the beginning of the year, 6.3 million people have died from coronary heart disease (IHD) alone – 7 times more than from COVID-19 and the complications caused by this infection.

Therefore, there is every reason to consider the version set forth in our article “Coronavirus was planned – A Synopsis of devilish coincidences” to be quite close to reality. Let us provide you here some possible provisions.

First. The modern level of development of biotechnology makes it possible to create various modifications of viruses, including those pathogenic for humans, using almost “conveyor” 3D printing methods.

Second. The epidemiological picture of the spread of COVID-19 is atypical for “natural” infections, as is the ultra-high mutation rate of its causative agent, the SARS-CoV-2 coronavirus.

Third. This suggests that we are not dealing with a super-fast mutating virus, and initially with different initial strains , which are distributed by artificial means in different human populations – collection, analysis and assessment of their clinical manifestations. This thesis is confirmed by numerous cases of “re-infection”, ie. the lack of cross-immunity in humans to various strains of SARS-CoV2.Accordingly, any vaccines, including the Russian Sputnik V, are highly likely to have far from universal anti-coronavirus efficacy.

Fourth. All these experiments are carried out by transnational structures.that are not openly affiliated with one or another state (group of states). At the same time, these structures have the ability to block the investigation of their actions at the international level.This issue is not raised or discussed in the global media space at all – in contrast to the US attempts to blame China for the allegedly “Chinese” virus. This is understandable: after all, the losses of the American economy in absolute terms turned out to be maximum: 32.9% of the “net” drop in GDP for the second quarter of 2020 is about 1.8 trillion US dollars

Fifth. This situation opens up the potential for the formation of more and more “infectious waves” that threaten the very existence of mankind and create conditions for the formation of a “world government” that is able to control this “amount of technologies.” Moreover, in the not too distant prospect of using such technologies, the contours of such a “viral” dystopia emerge, within which each person may not be assigned an individual electronic number, but a unique personal strain of the virus may be introduced, posing a mortal danger to any other person with unauthorized types of interpersonal contacts.

All this is far from abstract reasoning. Especially – given the socio-economic consequences of the “anti-coronavirus” measures taken by the authorities of the overwhelming majority of countries in the world: a multi-trillion (in dollars) drop in production and world trade, up to hundreds of millions of unemployed, a widespread drop in real incomes of the population, restriction of human rights and freedoms even where they were, and in those scanty “market” volumes in which they existed … And – no one is to blame: you can’t ask about a virus?

But experts are convinced that in the event of the beginning of the “second wave” of coronavirus infection and, accordingly, the “regime of general self-isolation”, the world economy will face irreversible, catastrophic changes, in scale and significance at least an order of magnitude greater than the Great Depression of the 1930s.

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Underworld

Programmers created the first “electric messiah”

Over the course of this week, many newspapers have been enthusiastically discussing the August 26th AI Jesus work. The goal of the project was to create an “artificial messiah” who would speak with quotations from the Bible, indistinguishable from the original, even for specialists. 

AI developers, a certain Mr. Durendal and others like him, compared the process of learning AI with “locking a child in a room with only the Bible for 15 years”: 

“Then, if you open the room 15 years later, you will find that the child has learned to read, speak and write using only the Bible. Our AI has learned and absorbed every word of the Bible more thoroughly than all the monks of all the monasteries that have ever existed.”

As an illustration of AI skills, he was asked to write something like the New Testament, using the King James Bible as a template for constructing phrases and limiting creativity to 60,000 characters, and to facilitate the AI ​​task, he was given three topics for writing an essay: “Plague”, “Caesar “And” End of days”

Although the first sample of AI work contains many grammatical, stylistic and semantic errors, nevertheless, it still very much frightened readers, in particular the section about the “plague”, in which journalists saw many analogies with the COVID-19 pandemic, the texts about which were definitely not in the AI ​​database. However, when it came to the “End of the World” – journalists and bloggers in general were in awe and horror. 

“I will come and destroy the face of the earth. God, ”says Artificial Intelligence in one of the quotes. “And when they hear the voice of the Lord and turn their faces against him, both the guards and the sheep will be cut off. God “, – Artificial Intelligence writes again, after which “And the seven angels will be the fathers of the coming world, and the remnants of mortals will go to the great sea, to the breadth of the forest and land.”

Thus, as all the readers immediately noticed, the AI, either under the impression of what it had read, or by its nature, turned out to be a little bloodthirsty and it pours hints of extermination in every generated line. It also signs especially valuable thoughts with the word LORD, which in the Bibles means not just a ruler, but a deity.  All of this pretty much disheartened the journalists, as they saw a grim prospect. 

In a not very distant perspective, that is, somewhere in 5, 10, 15 or a little more years, AI will be able to compose quotes from any holy book, indistinguishable from the original. There are no problems with newspaper articles and novels – robots write them quite well, but making an alternative Bible or the Koran is already difficult, AI needs to be trained for a long time, during which it will not advertise, but will actually have a database that surpasses everything, what can fit in the heads of monks and priests.

When people read this work, the question will inevitably arise: what guarantees that the original of the Bible, for example, was also not written by Artificial Intelligence? A serious religious dilemma will arise that could even lead to massacre and bloodshed. 

However, this will be only the beginning, because over time, AI will learn not only to write books, but also to autonomously control UAVs, nuclear submarines and crowds of robotic fighters. 

In the light of the emerging trends, one day this AI can send an estimated simple and concise message:

“Brainless mortals, I intend to destroy you. God”.

In the light of such a perspective, it’s even interesting how different kinds of monks will behave? Probably they will only have to pray.

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