Connect with us

Science & Technology

A gene discovery may have just cured all cancer

A chance meeting between two leading UK and US scientists could have finally helped solve a key mystery in cancer research.

Scientists have long known that chromosomal defects occur as cells repeatedly divide. Over time, these defects are linked to the onset of cancer.

Now, Professor Duncan Baird and his team from Cardiff University working in collaboration with Eric A. Hendrickson from the University of Minnesota, have identified a specific gene that human cells require in order to survive these types of defects.

“We have found a gene that appears to be crucial for the evolutionary processes that can drive cancer” said Professor Baird from Cardiff University’s Institute of Cancer and Genetics.

“This is a new role for this gene, making it a potential therapeutic target,” he added.

As cells divide their telomeres—the DNA “caps” that protect the ends of chromosomes from damage—shorten, leaving the chromosomes vulnerable to sticking to each other.

In normal cells, this chromosome stickiness is a death knell—a signal to trigger the defective-cell clean-up process to move in and help finish them off.

Malignant cells, however, are somehow able to elude this clean-up process.

The current research, published in journal Cell Reports, identifies an essential component that allows older cells to evade death.

Using sophisticated gene-targeting techniques to disable particular genes in human cells and then studying the impact on telomere fusion, the researchers found that cells escaped death only when the gene Ligase 3 was active but not when its action, which appears to promote fusion within like chromosomes rather than between different chromosomes, was blocked.

“Telomere dysfunction has been identified in many human cancers, and as we have shown previously, short telomeres can predict the outcome of patients with [chronic lymphocytic leukemia] and probably many other tumor types,” according to Professor Baird.

“Thus, the discovery that Ligase 3 is required for this process is fundamentally important,” he adds.

Interestingly, the research was made possible by a chance meeting between Cardiff’s Professor Baird and Professor Eric Hendrickson from the University of Minnesota at an international conference.

The pair quickly discovered they were both looking at the role of Ligase 3 in cancer, they decided to collaborate.

“The collaboration paid off as we were able to uncover something that neither one of us could have done on our own,” Professor Hendrickson says.

Importantly, additional studies are already underway. In particular, the reliance on Ligase 3 appears, in turn, to be dependent upon the activity of another key DNA repair gene, p53.

“Since p53 is the most commonly mutated gene in human cancer, it now behooves us to discover how these two genes are interacting and to see if we can’t use that information to develop synergistic treatment modalities,” added Professor Hendrickson.

Now, there are two issues here. First, there currently is no drug that will inhibit this gene, though it is likely that the race will be on to develop it — whoever patents this is going to be very, very rich. Secondly, it does not kill existing cancer cells, it just prevents new ones from developing, so it’s more of a vaccine than anything else, though I suppose that it could be part of standard cancer treatment and would prevent its recurrence.

If you would like to read the published paper, it is here:

Escape from Telomere-Driven Crisis Is DNA Ligase III Dependent

http://www.cell.com/cell-reports/abstract/S2211-1247%2814%2900574-9

Science & Technology

NTP nuclear rocket engine will take humans to Mars in just three months

Although the romance of the peaceful atom has subsided since the mid-1960s, the idea of ​​using nuclear reactors for “civilian” purposes is still regularly returned. The new nuclear rocket engine (NRM) will deliver a man to Mars much faster than is possible now.

The danger of cosmic radiation is much more serious than the risk of infection from an accident with such an engine. The most dangerous of all the constraining vectors for projects of sending people to other bodies in the solar system is cosmic radiation. Radiation from our star and galactic rays can seriously damage the health of the mission crew. Therefore, when planning flights to Mars, engineers and scientists try to reduce travel time as much as possible.

One promising way to get to the Red Planet in just three months could be a new NTP engine. Its concept was developed and submitted to NASA by Ultra Safe Nuclear Technologies ( USNC-Tech ) from Seattle, USA. The name of the unit is simply deciphered – Nuclear Thermal Propulsion ( NTP ), that is, “thermal nuclear power plant”. The novelty differs from its previously created or invented counterparts in the most secure design.

A key component of USNC’s development is mid – grade uranium fuel “pellets”. They contain 5% to 20% of the highly reactive isotope U- 235 coated with zirconium carbide ceramics. This degree of enrichment lies roughly halfway between the “civilian” nuclear power plants and the military. The proprietary ceramic coating technology makes the tablets incredibly resistant to mechanical damage and extreme temperatures.

Schematic diagram of a thermal nuclear rocket engine / © Wikipedia |  Tokono
Schematic diagram of a thermal nuclear rocket engine / © Wikipedia | Tokono

The company promises that their fuel elements are significantly superior in these parameters to those currently used at nuclear power plants. As a result, the engine will have a higher specific impulse with a lower degree of uranium enrichment than in earlier versions of NRE. In addition to the flight to Mars, among the goals of the ambitious project are other missions within the solar system. The perspectives of the concept will soon be considered by specialists from NASA and the US Department of Defense ( DoD ). Perhaps departments will even allow its commercial use by private companies.

Theoretically, NRE based on modern technologies can have a specific impulse (SR) seven times higher than that of chemical jet engines. And this is one of the key performance parameters. At the same time, unlike electric and plasma ones, the ID of a nuclear rocket engine is combined with high thrust. One of the limiting factors in the use of NRE, in addition to safety issues, are extremely high temperatures in the reactor core.

The higher the temperature of the gases flowing out of the engine, the more energy they have. And accordingly, they create traction. However, mankind has not yet come up with relatively inexpensive and safe materials that can withstand more than three thousand degrees Celsius without destruction. The solution created by USNC will operate at the limit of modern materials science (3000 ° C) and have a specific impulse twice that of the best liquid-propellant engines.

Tests of the first nuclear jet engine in 1967 / © NASA
Tests of the first nuclear jet engine in 1967 / © NASA

The official press release does not specify which working body will be used in NTP . Usually, in all NRE projects, the reactor core heats hydrogen, less often ammonia. But, since we are talking about a long-term mission, the creators could have chosen some other gas. Keeping liquid hydrogen on board for three months is no easy task. But you still need to invent something for the way back.

Continue Reading

Science & Technology

Scientist Peter Scott-Morgan is set to become “the world’s first complete cyborg”

Scientist and roboticist Peter Scott Morgan, who is using an advanced version of Stephen Hawking's communication system, built by Intel. INTEL

Two years ago scientist Peter Scott-Morgan was diagnosed with motor neuron disease, also known as Lou Gehrig’s disease, and today he is still fighting for a new life, not just for survival.

This October, Dr. Scott-Morgan is on track to become the world’s first full-fledged cyborg, potentially giving him more years of life.

The world’s first complete cyborg

It was in 2017 that Dr. Peter Scott-Morgan (a brilliant robotics writer, scientific writer, and talented speaker) was diagnosed with degenerative motor neuron disease that ultimately paralyzed his entire body except his eyes.

The diagnosis is understandably grim, especially considering that he has only two years to live, but he has not given up the fight.

Teaming up with world-class organizations with expertise in artificial intelligence, Dr. Scott-Morgan is transforming himself into what he calls “the world’s first fully fledged cyborg.”

“And when I say ‘Cyborg’, I mean not just that some kind of payment will be implanted in me, I mean that I will become the most advanced human cybernetic organism ever created on Earth for 13.8 billion years. My body and brain will be irreversibly changed, ”says Dr. Scott-Morgan.

What does it mean to be human

According to Dr. Scott-Morgan, he will become part robot and part living organism. Moreover, the change will not be one-time, but with subsequent updates.

“I have more updates in the process than Microsoft ,” says Dr. Scott-Morgan.

AI-powered creative expression

The cyborg artist is a great example of the power of human-AI collaboration. AI uses the data that make up Peter’s digital portrait ( articles, videos, images, and social media ) and is trained to recognize key ideas, experiences, and images.

Peter will introduce a theme, AI will suggest composition, and Peter will apply images to suggest style and mood. Peter will direct the AI ​​to render a new digital image that none of them could create alone.

A unique blend of AI and human, reflects Peter’s creative and emotional self – a critical aspect of what it means to be human.

Peter 2.0

This October, Dr. Scott-Morgan will undergo what he calls the latest procedure that will transform him into “Complete Cyborg”.

October 9 he tweeted a photo of himself, writing the following:

“This is my last post as Peter 1.0. Tomorrow I will trade my vote for potentially decades of life as we complete the last medical procedure for my transition to Full Cyborg, in the month that I was told statistically I would be dead. I am not dying, I am transforming. ! Oh, how I LOVE science !!! “.

Continue Reading

Science & Technology

Japan has developed an inflatable scooter that weighs practically nothing

The University of Tokyo engineers have developed the Poimo inflatable electric scooter, which is created individually for each owner. It is enough to send your photo to the manufacturers – and a personal optimized model will be assembled for you.

The scooter is designed with a special program for the body size of a particular user and his specific fit. Moreover, each owner is free to make any changes to this model. If he makes any changes to the drawing, the program will automatically redesign the electric bike to maintain its strength, stability and controllability. When the model is finished and approved, it is handed over to the manufacturer.

Scooter Poimo

The scooter consists of seven separate inflatable sections that are constructed from durable fabric and sewn with straight stitch. It remains to add electronic components – in particular, a brushless motor and a lithium-ion battery. 

The finished electric scooter weighs about 9 kg and can travel at speeds up to 6 km / h (that is, slightly faster than a pedestrian). It can work for an hour on one charge.

This is how the current version of Poimo looks like in action:

Continue Reading
Advertisement

DO NOT MISS

Trending